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Biochimica et Biophysica Acta - Gene Regulatory Mechanisms(1)
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scopus(11)
An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
ReviewAbstract: Importance of the field: The increase in life expectancy in developed countries has given rise to sePalabras claves:Alzheimer's disease, apoptosis, Neuroprotective drugs, Parkinson's DiseaseAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Sureda F.X., Verdaguer E., Zárate C.B.Fuentes:scopusGlutamate excitotoxicity activates the MAPK/ERK signaling pathway and induces the survival of rat hippocampal neurons in vivo
ArticleAbstract: Current knowledge concerning the molecular mechanisms of the cellular response to excitotoxic insultPalabras claves:glutamate, hippocampus, MAPK/ERK, neuroprotection, NeurotoxicityAutores:Antoni Camins, González R.M., Huerta V.C., Lemus L., Ortuo-Sahagún D., Rivera-Cervantes M.C., Torres-Mendoza B.M., Verdaguer E., Zárate C.B.Fuentes:scopusHigh-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents
ArticleAbstract: Global obesity is a pandemic status, estimated to affect over 2 billion people, that has resulted inPalabras claves:Alzheimer disease, APPswe/PS1dE9, hippocampus, insulin receptor, Mitochondria, TauAutores:Antoni Camins, Artiach G., Barroso E., Carro E., Casadesús G., Ferrer I., Folch J., Pallás M., Pedros I., Petrov D., Sureda F.X., Vázquez-Carrera M., Zárate C.B.Fuentes:scopusEpigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice
ArticleAbstract: Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated fPalabras claves:APPswe/PS1dE9 mice, Cognitive deficits, Epigallocatechin-3-gallate, hippocampus, obesity, unfolded protein responseAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Castro-Torres R.D., Ettcheto M., Folch J., García M.L., Manzine P.R., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusEvaluation of neuropathological effects of a high-fat diet in a presymptomatic Alzheimer's disease stage in APP/PS1 mice
ArticleAbstract: Alzheimer's disease (AD) is currently an incurable aging-related neurodegenerative disorder. RecentPalabras claves:Alzheimer's disease, APPswe/PS1dE9, hippocampus, insulin receptor, Mitochondria, TauAutores:Alva N., Antoni Camins, Auladell C., Carbonell T., Ettcheto M., Folch J., Pallás M., Pedros I., Petrov D., Zárate C.B.Fuentes:scopusThe Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia
ReviewAbstract: Nowadays, Alzheimer’s disease (AD) is a severe sociological and clinical problem. Since it was firstPalabras claves:Alzheimer’s disease, Insulin Resistance, Mediterranean diet, neuroinflammation and neurodegeneration, obesity, Type 2 Diabetes mellitusAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Cano A., Casadesús G., Espinosa-Jimenez T., Ettcheto M., Folch J., García M.L., Olloquequi J., Sanchez-Lopez E., Zárate C.B.Fuentes:scopusThe role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin
ReviewAbstract: Leptin (Lep) is emerging as a pivotal molecule involved in both the early events and the terminal phPalabras claves:Alzheimer's disease, amylin, Ghrelin, high-fat diet, hippocampus, insulin receptor, leptin, mTOR, obesity, PGC-1α, prolactinAutores:Abad S., Antoni Camins, Ettcheto M., Folch J., Martínez N., Miguel Marin, Patraca I., Pedros I., Petrov D., Zárate C.B.Fuentes:scopusSirtuin activators: Designing molecules to extend life span
ReviewAbstract: Resveratrol (RESV) exerts important pharmacological effects on human health: in addition to its benePalabras claves:DIABÉTES, neurodegenerative diseases, Resveratrol, Sirtuin activators, SirtuinsAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Sureda F.X., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusLack of Jun-N-terminal kinase 3 (JNK3) does not protect against neurodegeneration induced by 3-nitropropionic acid
ArticleAbstract: Aims: 3-Nitropropionic acid (3-NP) is a toxin that replicates most of the clinical and pathophysioloPalabras claves:Huntington, JNK3, Neurodegeneration, Nitropropionic acidAutores:Antoni Camins, Auladell C., De Lemos M.L., Folch J., Junyent F., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusResveratrol: An antiaging drug with potential therapeutic applications in treating diseases
ReviewAbstract: The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the dPalabras claves:Alzheimer’s disease, Parkinson’s Disease, Resveratrol, Sirt1Autores:Antoni Camins, Junyent F., Ortuo-Sahagún D., Pallás M., Rojas-Mayorquín A.E., Verdaguer E., Zárate C.B.Fuentes:scopus