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Review Backbone N-Modified Peptides: How to Meet the Challenge of Secondary Amine Acylation
ArticleAbstract: Backbone N-substitution of peptides (N-Me and N-alkyl) has become of special interest as a chemicalPalabras claves:acylation, coupling reagent, methylationAutores:Alberício F., Fernandez-Llamazares A.I., Jan SpenglerFuentes:googlescopusTackling lipophilicity of peptide drugs: Replacement of the backbone n -methyl group of Cilengitide by N -oligoethylene glycol (N -OEG) chains
ArticleAbstract: Cilengitide is an RGD-peptide of sequence cyclo[RGDfNMeV] that was was developed as a highly activePalabras claves:Autores:Adan J., Alberício F., Fernandez-Llamazares A.I., Jan Spengler, Mitjans F.Fuentes:googlescopusThe backbone N-(4-azidobutyl) linker for the preparation of peptide chimera
ArticleAbstract: A robust synthetic strategy for the introduction of the N-(4-azidobutyl) linker into peptides usingPalabras claves:Autores:Adan J., Alberício F., Fernandez-Llamazares A.I., García J., Jan Spengler, Meunier D., Mitjans F.Fuentes:googlescopusThe potential of N-alkoxymethyl groups as peptide backbone protectants
ArticleAbstract: In this study, the potential of N-alkoxymethyl groups as protectants for the peptide backbone has bePalabras claves:Backbone N-alkylation, Backbone protecting groups, N-Alkoxymethyl, Peptides, SPPSAutores:Alberício F., Fernandez-Llamazares A.I., Jan SpenglerFuentes:googlescopus