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Bacteria Hunt Bacteria through an Intriguing Cyclic Peptide
ReviewAbstract: In the last few decades, peptides have been victorious over small molecules as therapeutics due to tPalabras claves:Antibiotics, biological activity, cyclic antimicrobial peptides, Drug Discovery, PeptidesAutores:Alberício F., B. G. De la Torre, El-Faham A., Monaim S.A.H.A., Somboro A.M.Fuentes:scopus1,3,5-Triazino Peptide Derivatives: Synthesis, Characterization, and Preliminary Antileishmanial Activity
ArticleAbstract: A library of short di-, tri-, and tetra-peptides with an s-triazine moiety at the N terminus and eitPalabras claves:1,3,5-triazine derivatives, antileishmanial compounds, morpholines, Peptides, piperidinesAutores:Abd El-Rahman M.M., Alberício F., B. G. De la Torre, Bekhit A.A., El-Faham A., Khalil H.H., Khattab S.N.Fuentes:scopus2018 FDA Tides Harvest
ReviewAbstract: In 2018, the United States Food and Drug Administration (FDA) approved a total of 59 new drugs, threPalabras claves:Dotatate, drugs, Inotersen, Lutathera, Oligonucleotides, Onpattro, Patisiran, Peptides, Pharmaceutical market, TegsediAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopus2022 FDA TIDES (Peptides and Oligonucleotides) Harvest
ArticleAbstract: A total of 37 new drug entities were approved in 2022; although that year registered the lowest numbPalabras claves:drugs, FDA, gadopiclenol, lutetium ( Lu) vipivotide tetraxetan 177, Oligonucleotides, Peptides, terlipressin, tirzepatide, vutrisiranAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopusCell Penetrating Peptides as potential drug carriers
ReviewAbstract: The discovery and development of natural, synthetic or peptidomimetic cell-penetrating peptides (CPPPalabras claves:Blood-brain barrie, Cell penetrating peptides, Molecular transportes, PeptidesAutores:Alberício F., Hortensia Rodriguez Cabrera, Pulido X.C., Royo M.Fuentes:scopusEDC·HCl and Potassium Salts of Oxyma and Oxyma-B as Superior Coupling Cocktails for Peptide Synthesis
ArticleAbstract: Nowadays, DIC is the most widely used carbodiimide for solid-phase peptide synthesis, while EDC·HClPalabras claves:peptide coupling, Peptides, solid-phase synthesis, Steric hindrance, synthetic methodsAutores:Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Khattab S.N., Kruger H.G.Fuentes:scopusNew manufacturing process to produce highly uniform resins with excellent performances in Solid Phase Peptide Synthesis
ArticleAbstract: Peptides are an important class of Active Pharmaceutical Ingbkp_redients. Thanks to the implementatiPalabras claves:Jetting manufacturing, loading, Peptides, Polystyrene, SPPS, swellingAutores:Alberício F., B. G. De la Torre, Basso A., Cheng J.I., East N.R., Jad Y.E., Kumar A., Musaimi O.A.L., Serban S., Zhichao M.A.Fuentes:scopusOxymaPure Coupling Reagents: Beyond Solid-Phase Peptide Synthesis
ArticleAbstract: OxymaPure [ethyl 2-cyano-2-(hydroxyimino)acetate] is an exceptional reagent with which to suppress rPalabras claves:amide bonds, coupling reagent, Peptides, Racemization, solid-phase synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Manne S.R.Fuentes:scopusIncorporation of the α-mercapto acid unit into peptides
ArticleAbstract: Incorporation of α-mercapto acid units into the backbone of potential drug candidates improves the mPalabras claves:Acylations, Dielectrophiles, Hexafluoroacetone, Peptides, Thiols, Thiomalic acidAutores:Alberício F., Burger K., Haas A., Jan Spengler, Pumpor K.Fuentes:googlescopusK-Oxyma: A strong acylation-promoting, 2-ctc resin-friendly coupling additive
ArticleAbstract: Here we present a new formulation of the recently introduced OxymaPure additive for peptide bond forPalabras claves:Acid-labile solid supports, acylation, Peptides, solid-phase synthesisAutores:Acosta G.A., Alberício F., Cherkupally P., El-Faham A., Hortensia Rodriguez Cabrera, Jan Spengler, Khattab S.N., Luxembourg Y., Nieto-Rodriguez L., Prohens R., Shamis M., Subiros-Funosas R.Fuentes:scopus