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Article(9)
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Current Topics in Medicinal Chemistry(2)
Journal of Ethnopharmacology(2)
ACS Chemical Neuroscience(1)
Bioorganic and Medicinal Chemistry Letters(1)
Epilepsy and Behavior(1)
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Química y ciencias afines(3)
Bioquímica(2)
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Medicina y salud(1)
Plantas conocidas por sus características y flores(1)
Anti-inflammatory activity and cheminformatics analysis of new potent 2-substituted 1-methyl-5-nitroindazolinones
ArticleAbstract: After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroiPalabras claves:Anti-inflammatory compound, Nitroindazolinones, SARANEA software, Structure-activity relationship, TPA-induced mouse ear edema, zebrafishAutores:Andújar I., Arán V.J., Crawford A.D., De Witte P.A.M., Díaz-Mendoza C., Giner R.M., Manjarrez G., María Lorena Cordero-Maldonado, Pérez-Jiménez F., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:scopusAnti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
ArticleAbstract: Ethnopharmacological relevance: Epilepsy is one of the major chronic diseases that does not have a cPalabras claves:Epilepsy, Pleiocarpamine, Rauverine H, Rauvolfia caffra, zebrafishAutores:Chen W., Chipiti T., Crawford A.D., Enslin G.M., María Lorena Cordero-Maldonado, Sandasi M., Van Heerden F.R., Veale C.G.L., Viljoen A.M.Fuentes:scopusAnticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
ArticleAbstract: Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional mediciPalabras claves:Ar-turmerone, Bisabolene sesquiterpenoids, curcuma longa, Mouse PTZ model, Pentylenetetrazole, Turmeric, turmeric oil, zebrafish PTZ model, α,β-Turmerone, α-AtlantoneAutores:Adriana Orellana-Paucar, Afrikanova T., Alen J., Crawford A.D., De Borggraeve W., De Witte P.A.M., Esguerra C.V., Fabián León-Tamariz, Maes J., Serruys A.S.K., Wilches IsabelFuentes:googlescopus2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes
ArticleAbstract: The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liPalabras claves:2-Octadecynoic acid, Acetylenic fatty acids, Blood stage, Liver stage, MALARIA, plasmodium, Type II fatty acid synthaseAutores:Andricopulo A.D., Bwalya A.G., Carballeira N.M., Crawford A.D., Guido R.V.C., Itoe M.A., Kaiser M., María Lorena Cordero-Maldonado, Mota M.M., Tasdemir D.Fuentes:scopusFishing anti-inflammatories from known drugs: In silico repurposing, design, synthesis and biological evaluation of bisacodyl analogues
ArticleAbstract: Herein is described in silico repositioning, design, synthesis, biological evaluation and structure-Palabras claves:Anti-inflammatory assay, Anti-inflammatory database, Atom-based bilinear indices, Bisacodyl, Diarylmethylpyridines, Repurposing, ToMoCoMD-CARDD softwareAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Dumas F., Ferroud C., Giner R.M., Guerra Y.R., Lerari V., Marín M., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:googlescopusEvaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays
ArticleAbstract: Ethnopharmacological relevance: In South Africa, medicinal plants have a history of traditional use,Palabras claves:Cotyledon orbiculata, Lobostemon fruticosus, Pro-angiogenesis, Scabiosa columbaria, Traditional medicine, Wound healing, zebrafishAutores:Crawford A.D., Hattingh A.C., Katerere D., Koekemoer T.C., María Lorena Cordero-Maldonado, Mhlongo F., Sandasi M., van de Venter M., Viljoen A.M.Fuentes:scopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusIntegration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products
ArticleAbstract: Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovPalabras claves:Autores:Bohni N., Crawford A.D., De Witte P.A.M., Esguerra C.V., Kamuhabwa A.R., Maes J., Marcourt L., María Lorena Cordero-Maldonado, Moshi M.J., Munck S., Siverio-Mota D., Wolfender J.L.Fuentes:rraaescopusTanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models
ArticleAbstract: Danshen or Chinese red sage (Salvia miltiorrhiza, Bunge) is used by traditional Chinese medicine (TCPalabras claves:mouse seizure models, pentylenetetrazol, Salvia miltiorrhiza, Tanshinone IIA, zebrafish PTZ modelAutores:Adriana Orellana-Paucar, Buenafe O.E., Crawford A.D., De Borggraeve W., De Witte P.A.M., Esguerra C.V., Huang H., Luyten W., Maes J., Ying X.Fuentes:googlescopus