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Calpains as a target for therapy of neurodegenerative diseases: Putative role of lithium
ReviewAbstract: Lithium is a simple cation that has been used clinically since 1950 for the treatment of bipolar disPalabras claves:apoptosis, Calcium homeostasis, Calpain, Cell cycle control, Cytoskeleton, DNA damage, Kinases, Lithium, Neurodegeneration, neurodegenerative diseases, signal transduction, Tau kinasesAutores:Antoni Camins, Canudas A.M., Crespo-Biel N., Junyent F., Pallás M., Verdaguer E.Fuentes:scopusOxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line
ArticleAbstract: Reactive oxygen species and oxidative stress are associated with neuronal cell death in many neurodePalabras claves:apoptosis, ATM, cell cycle, KU-55933, Retinoblastoma proteinAutores:Antoni Camins, Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Vázquez De La Torre A., Verdaguer E.Fuentes:scopusResveratrol: An antiaging drug with potential therapeutic applications in treating diseases
ReviewAbstract: The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the dPalabras claves:Alzheimer’s disease, Parkinson’s Disease, Resveratrol, Sirt1Autores:Antoni Camins, Junyent F., Ortuo-Sahagún D., Pallás M., Rojas-Mayorquín A.E., Verdaguer E., Zárate C.B.Fuentes:scopusRole of cdk5 on ATM phosphorylation in neuronal death induced by DNA damage
ArticleAbstract: This study demonstrates that Cdk5 phosphorylates ataxia-telangiectasia mutated protein (ATM) at Ser7Palabras claves:Autores:Antoni Camins, Junyent F., Pallás M., Verdaguer E.Fuentes:scopusPrevention of epilepsy by taurine treatments in mice experimental model
ArticleAbstract: An experimental model based on kainic acid (KA) injections replicates many phenomenological featuresPalabras claves:Kainic acid, Neurodegeneration, neuroprotectionAutores:Antoni Camins, Auladell C., Duque D., Junyent F., Pallás M., Romero R., Utrera J.Fuentes:scopusPotential mechanisms involved in the prevention of neurodegenerative diseases by lithium
ReviewAbstract: Lithium is a monovalent cation that was introduced in 1949 by John Cade for the treatment of bipolarPalabras claves:Alzheimer disease, Autophagy, GSK-3β, Lithium, Oxidative Stress, Parkinson DiseaseAutores:Antoni Camins, Junyent F., Pallás M., Pelegrí Gabalda C., Verdaguer E., Vilaplana J., Yeste-Velasco M.Fuentes:scopusSynthesis, uptake and release of taurine in astrocytes treated with 8-Br-cAMP
ArticleAbstract: Taurine is one of the most abundant free amino acids in the mammalian central nervous system, wherePalabras claves:8-Br-AMPc, astrocytes, Cysteine sulfinic decarboxylase, taurineAutores:Antoni Camins, Auladell C., Junyent F., Pallás M., Romero R., Utrera J.Fuentes:scopus