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An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
ReviewAbstract: Importance of the field: The increase in life expectancy in developed countries has given rise to sePalabras claves:Alzheimer's disease, apoptosis, Neuroprotective drugs, Parkinson's DiseaseAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Sureda F.X., Verdaguer E., Zárate C.B.Fuentes:scopusATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation
ArticleAbstract: Ataxia telangiectasia mutated protein (ATM) is a member of the phosphatidylinositol-3 kinase (PI3K)Palabras claves:apoptosis, ATM, cell cycle, KU-55933, Retinoblastoma protein, siRNAAutores:Antoni Camins, de la Torre A.V., Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Verdaguer E.Fuentes:scopusActivation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
ArticleAbstract: In the present study we demonstrated that neurotoxin MPP +-induced DNA damage is followed by ataxiaPalabras claves:apoptosis, ATM, B65 neuroblastoma, cell cycle, MPP +, Parkinson's Disease, Retinoblastoma proteinAutores:Alvira D., Antoni Camins, de la Torre A.V., Ferrer I., Folch J., Gutiérrez-Cuesta J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Sureda F.X., Verdaguer E.Fuentes:scopusAging control with resveratrol
ReviewAbstract: The prevalence of age-related pathologies such as neurodegenerative disease and diabetes type II hasPalabras claves:Autores:Antoni Camins, Junyent F., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusEffects of MPP<sup>+</sup> on the molecular pathways involved in cell cycle control in B65 neuroblastoma cells
ArticleAbstract: The toxicity caused by cell exposure to 1-methyl-4-phenylpyridinium ion (MPP+) is a useful model inPalabras claves:apoptosis, Caspases, cell cycle, γH2AXAutores:Antoni Camins, Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Verdaguer E., Zárate C.B.Fuentes:scopusSystemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes
ArticleAbstract: The intraperitoneal administration of 3-nitropropionic acid, which is commonly used to induce toxiciPalabras claves:apoptosis, Huntington's disease, Neurodegeneration, RAT, Striatum, TUNELAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Junyent F., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusTau hyperphosphorylation and axonal damage induced by N,N- diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthood
ArticleAbstract: Axonal degeneration has been described as the pathological hallmark of peripheral neuropathies inducPalabras claves:Axonal damage, DEDTC, Postnatal development, Tau phosphorylationAutores:Antoni Camins, Auladell C., De Lemos M.L., Junyent F., Pallás M., Romero R., Utrera J.Fuentes:scopusTaurine treatment inhibits CaMKII activity and modulates the presence of calbindin D28k, calretinin, and parvalbumin in the brain
ArticleAbstract: Taurine, 2-aminoethanesulfonic acid, is present at high concentrations in many invertebrate and vertPalabras claves:Calbindin D28k, Calretinin, CAMKII, Parvalbumin, taurineAutores:Antoni Camins, Auladell C., De Lemos M.L., Junyent F., Pallás M., Romero R., Utrera J.Fuentes:scopusNeuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)
ArticleAbstract: Dietary interventions have been proposed as a way to increase lifespan and improve health. The senesPalabras claves:ADAM10, ageing, BDNF, Neurodegeneration, NFκB, Sirtuin 1Autores:Antoni Camins, Folch J., Gutiérrez-Cuesta J., Jiménez A., Junyent F., Lau A., Ortuo-Sahagún D., Pallás M., Tajes M., Verdaguer E.Fuentes:scopusNovel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates
ArticleAbstract: A new family of dual binding site acetylcholinesterase (AChE) inhibitors has been designed, synthesiPalabras claves:Acetylcholinesterase, drug design, Inhibitors, β-amyloid peptides, β-secretaseAutores:Andrisano V., Antoni Camins, Arce M.P., Badia A., Bartolini M., Bidon-Chanal A., Camps P., Clos M.V., Galdeano C., Gómez T., Junyent F., Luque F.J., Mancini F., Muñoz-Torrero D., Pallás M., Ramírez L., Ratia M., Rodríguez-Franco M.I., Verdaguer E., Viayna E.Fuentes:scopus