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Breaking a Couple: Disulfide Reducing Agents
ReviewAbstract: Cysteine is present in a large number of natural and synthetic (bio)molecules. Although the thiol siPalabras claves:Cysteine, cystine, Disulfide bridges, reducing agents, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopus2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents
ArticleAbstract: Disulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synPalabras claves:Autores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusExploring the orthogonal chemoselectivity of 2,4,6-trichloro-1,3,5-triazine (TCT) as a trifunctional linker with different nucleophiles: Rules of the game
ArticleAbstract: The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyPalabras claves:density functional theory, Electrostatic potential maps, NBO calculations, S-triazine, Triorthogonal linkerAutores:Alberício F., B. G. De la Torre, El-Faham A., Sharma A.Fuentes:scopusDisulfide-Based Protecting Groups for the Cysteine Side Chain
ArticleAbstract: Two new disulfide-based protecting groups (SIT and MOT) are proposed for Cys thiol in the substitutiPalabras claves:Autores:Alberício F., B. G. De la Torre, Chakraborty A., Sharma A.Fuentes:scopusN-methylation in amino acids and peptides: Scope and limitations
ReviewAbstract: Active pharmaceutical ingbkp_redients (APIs) can be divided into two types, namely chemical and biolPalabras claves:cyclic peptides, NMAA, side-reactions, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A., Monaim S.A.H.A., Sharma A.Fuentes:scopusNovel pyrazolyl-s-triazine derivatives, molecular structure and antimicrobial activity
ArticleAbstract: A new series of pyrazole-containing s-triazine derivatives were synthesized by reaction of the correPalabras claves:Antibacterial activities, Cyanuric chloride, DFT/B3LYP, Hydrazino-s-triazine, Pyrazole, X-ray crystallographyAutores:Alberício F., B. G. De la Torre, El-Faham A., Ghabbour H.A., Khan S.T., Sharma A.Fuentes:scopusIn situ Fmoc removal - a sustainable solid-phase peptide synthesis approach
ArticleAbstract: Solid-phase peptide synthesis (SPPS) is the strategy of choice for the synthesis of peptides for resPalabras claves:Autores:Alberício F., B. G. De la Torre, Kumar A., Sharma A.Fuentes:scopusInsights into the chemistry of the amphibactin–metal (M<sup>3+</sup>) interaction and its role in antibiotic resistance
ArticleAbstract: We have studied the diversity and specificity of interactions of amphibactin produced by Vibrio genuPalabras claves:Autores:Alberício F., B. G. De la Torre, Kaipanchery V., Sharma A.Fuentes:scopusLiquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides
ReviewAbstract: Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in thPalabras claves:Autores:Alberício F., B. G. De la Torre, Kumar A., Sharma A.Fuentes:scopus