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Barbiturate- And Thiobarbituarte-Based s-Triazine Hydrazone Derivatives with Promising Antiproliferative Activities
ArticleAbstract: A new class of compounds, which include s-triazine with pyrimidinetrione or thiopyrimidinedione moiePalabras claves:Autores:Al-Rasheed H.H., Alberício F., B. G. De la Torre, Dahlous K.A., El-Faham A., Sharma A., Sholkamy E.N.Fuentes:scopusAcetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) via EGFR/PI3K/AKT/mTOR Signaling Cascades
ArticleAbstract: Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedPalabras claves:anticancer profile, apoptosis, DMF-DMA, EGFR/PI3K/AKT/mTOR, One-pot synthesis, pyrazolyl-s-triazineAutores:Al Zoubi M., Alberício F., Aldalbahi A., Alqudah D.A., Alshaer W., B. G. De la Torre, Barakat A., Daoud F., El-Faham A., Hatmal M.M., Haukka M., Nafie M.S., Sharma A., Shawish I.Fuentes:scopusDesign and synthesis of mono-and di-pyrazolyl-s-triazine derivatives, their anticancer profile in human cancer cell lines, and in vivo toxicity in zebrafish embryos
ArticleAbstract: s-Triazine is considered a privileged structure, as it is found in several FDA-approved drugs. In thPalabras claves:anticancer activity, Pyrazole, S-triazine, Zebrafish embryosAutores:Al-Dhfyan A., Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Farooq M., Sharma A., Taha N.A., Wadaan M.A.M.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusExploiting the Thiobarbituric Acid Scaffold for Antibacterial Activity
ArticleAbstract: Thiobarbituric acid (TBA) has been considered a privileged structure for developing antimicrobial agPalabras claves:Antibiotics, barbituric acid, nanoformulations, Thiobarbituric acidAutores:Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Hazzah H.A., Noki S., Sharma A., Zamisa S.J.Fuentes:scopusN-methylation in amino acids and peptides: Scope and limitations
ReviewAbstract: Active pharmaceutical ingbkp_redients (APIs) can be divided into two types, namely chemical and biolPalabras claves:cyclic peptides, NMAA, side-reactions, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A., Monaim S.A.H.A., Sharma A.Fuentes:scopusNovel 4,6-disubstituted s-triazin-2-yl amino acid derivatives as promising antifungal agents
ArticleAbstract: A novel series of 4,6-disubstituted s-triazin-2-yl amino acid derivatives was prepared and characterPalabras claves:2,4,6-trichlorotriazine, Antifungal, Candida Albicans, N-myristoltransferase, TCT, Triazine amino acidAutores:Alberício F., Alhameed R.A., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Khan S.A., Sharma A., Sholkamy E.N., Ul-Haq Z.Fuentes:scopusNovel pyrazolyl-s-triazine derivatives, molecular structure and antimicrobial activity
ArticleAbstract: A new series of pyrazole-containing s-triazine derivatives were synthesized by reaction of the correPalabras claves:Antibacterial activities, Cyanuric chloride, DFT/B3LYP, Hydrazino-s-triazine, Pyrazole, X-ray crystallographyAutores:Alberício F., B. G. De la Torre, El-Faham A., Ghabbour H.A., Khan S.T., Sharma A.Fuentes:scopusPerfluorophenyl derivatives as unsymmetrical linkers for solid phase conjugation
ArticleAbstract: Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two diffPalabras claves:Chimera, conjugation, Fluorolinkers, Peptide stapling, Solid-phase peptide synthesisAutores:Alapour S., Alberício F., B. G. De la Torre, Koorbanally N.A., Ramjugernath D., Sharma A.Fuentes:scopusLiquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides
ReviewAbstract: Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in thPalabras claves:Autores:Alberício F., B. G. De la Torre, Kumar A., Sharma A.Fuentes:scopus