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Barbiturate- And Thiobarbituarte-Based s-Triazine Hydrazone Derivatives with Promising Antiproliferative Activities
ArticleAbstract: A new class of compounds, which include s-triazine with pyrimidinetrione or thiopyrimidinedione moiePalabras claves:Autores:Al-Rasheed H.H., Alberício F., B. G. De la Torre, Dahlous K.A., El-Faham A., Sharma A., Sholkamy E.N.Fuentes:scopusBreaking a Couple: Disulfide Reducing Agents
ReviewAbstract: Cysteine is present in a large number of natural and synthetic (bio)molecules. Although the thiol siPalabras claves:Cysteine, cystine, Disulfide bridges, reducing agents, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopus1,3,5-Triazine as core for the preparation of dendrons
ArticleAbstract: A unique property of 2,4,6-trichloro-1,3,5-triazine (TCT) is its ability to undergoes a nucleophilicPalabras claves:1+2 mode, Dendron, HPLC, Nucleophiles, S-triazineAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A., Sheyi R.Fuentes:scopus2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents
ArticleAbstract: Disulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synPalabras claves:Autores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopusCrystal structure and theoretical investigation of thiobarbituric acid derivatives as nonlinear optical (NLO) materials
ArticleAbstract: Here we report on the crystal structure of three enamine/imine TBA derivatives (1−3). Since the deriPalabras claves:Crystals, DFT, Enamine/imine tautomer, Hyperpolarizability, NLOAutores:Al-Majid A.M., Al-Rasheed H.H., Alberício F., B. G. De la Torre, Barakat A., Choudhary M.I., El-Faham A., Sharma A., Yousuf S.Fuentes:scopusCrystal structure, spectroscopic studies and theoretical studies of thiobarbituric acid derivatives: understanding the hydrogen-bonding patterns
ArticleAbstract: In addition to their wide-ranging applications in the pharmaceutical industry, thiobarbituric acid (Palabras claves:Crystal structure, DFT calculations, IR spectroscopy, Thiobarbituric acid, Transition state, UV spectroscopy, X-ray crystallographyAutores:Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Noki S., Sharma A., Zamisa S.J.Fuentes:scopusAcetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl s-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) via EGFR/PI3K/AKT/mTOR Signaling Cascades
ArticleAbstract: Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedPalabras claves:anticancer profile, apoptosis, DMF-DMA, EGFR/PI3K/AKT/mTOR, One-pot synthesis, pyrazolyl-s-triazineAutores:Al Zoubi M., Alberício F., Aldalbahi A., Alqudah D.A., Alshaer W., B. G. De la Torre, Barakat A., Daoud F., El-Faham A., Hatmal M.M., Haukka M., Nafie M.S., Sharma A., Shawish I.Fuentes:scopusDesign and synthesis of mono-and di-pyrazolyl-s-triazine derivatives, their anticancer profile in human cancer cell lines, and in vivo toxicity in zebrafish embryos
ArticleAbstract: s-Triazine is considered a privileged structure, as it is found in several FDA-approved drugs. In thPalabras claves:anticancer activity, Pyrazole, S-triazine, Zebrafish embryosAutores:Al-Dhfyan A., Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Farooq M., Sharma A., Taha N.A., Wadaan M.A.M.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusExploiting the Thiobarbituric Acid Scaffold for Antibacterial Activity
ArticleAbstract: Thiobarbituric acid (TBA) has been considered a privileged structure for developing antimicrobial agPalabras claves:Antibiotics, barbituric acid, nanoformulations, Thiobarbituric acidAutores:Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Hazzah H.A., Noki S., Sharma A., Zamisa S.J.Fuentes:scopus