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Comparative Serum Analyses Identify Cytokines and Hormones Commonly Dysregulated as Well as Implicated in Promoting Osteolysis in MMP-2-Deficient Mice and Children
ArticleAbstract: Deficiency of matrix metalloproteinase 2 (MMP-2) causes a complex syndrome characterized by multicenPalabras claves:cortisol, cytokines, Matrix metalloproteinase, matrix metalloproteinase-2, multicentric osteolysis nodulosis and arthropathyAutores:Botto L.D., Eugenio Hardy, Fernandez‐Patron C., Haimour A., Karim M.A., Martignetti J.A., Sarker H., Scholl-Bürgi S.Fuentes:scopusDestroy to Rebuild: The Connection Between Bone Tissue Remodeling and Matrix Metalloproteinases
ReviewAbstract: Bone is a dynamic organ that undergoes constant remodeling, an energetically costly process by whichPalabras claves:bone, deficiency, Matrix metalloproteinase, metabolism, remodeling, underactivityAutores:Eugenio Hardy, Fernandez‐Patron C.Fuentes:scopusCould Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?
ArticleAbstract: Endogenous glucocorticoids and their synthetic analogues, such as dexamethasone, stimulate receptor-Palabras claves:ACE2 (angiotensin converting enzyme 2), cortisol, covid-19, Dexamethasone, glucocorticoids, innate immunity, SARS-COV-2, Spike proteinAutores:Eugenio Hardy, Fernandez‐Patron C.Fuentes:scopusActive immunization with human interleukin-15 induces neutralizing antibodies in non-human primates
ArticleAbstract: Background: Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune andPalabras claves:Alum, CTLL-2 cells, Cytokine, IL-15, Immunization, Neutralizing Abs, non-human primatesAutores:Besada-Pérez V., Castro-Velazco J., Chico-Capote A., Eugenio Hardy, Gerónimo-Pérez H., Martínez-Castillo R., Martínez-Cordovez K., Morera-Díaz Y., Puente-Pérez P., Rodríguez-Álvarez Y., Santos-Savio A.Fuentes:scopusDesign and validation of a diffusion cell for in vitro biomolecule release studies
ArticleAbstract: In this work, a new cell for the in vitro release of biomolecules was designed and built. The cell,Palabras claves:Diffusion cell, EGF, Epidermal growth factor, In vitro release, ValidationAutores:Aguilera A., Estevez T., Eugenio Hardy, Saez A.Fuentes:scopusExpression and folding of an interleukin-2-proinsulin fusion protein and its conversion into insulin by a single step enzymatic removal of the C-peptide and the N-terminal fused sequence
ArticleAbstract: We report the expression in E. coli of a proinsulin fusion protein carrying a modified interleukin-2Palabras claves:Enzymatic processing, Proinsulin folding, Recombinant insulinAutores:Besada-Pérez V., Castellanos‐Serra L., Eugenio Hardy, Falcón-Cama V., Fernandez C., Gonzalez M., Herrera L., Perez G., Santiago Nelson Vispo, Santos-Savio A., Silva A., Ubieta R.Fuentes:scopusEmerging pathways of communication between the heart and non-cardiac organs
ArticleAbstract: The breakthrough discovery of cardiac natriuretic peptides provided the first direct demonstration oPalabras claves:heart, inflammation, Liver, Matrix metalloproteinase, metabolism, microRNA, Natriuretic peptidesAutores:Eugenio Hardy, Fernandez‐Patron C.Fuentes:scopusHigh yield elution of proteins from sodium dodecyl sulfate- polyacrylamide gels at the low-picomole level. Application to N-terminal sequencing of a scarce protein and to in-solution biological activity analysis of on-gel renatured proteins
Conference ObjectAbstract: A simple, reliable procedure for practically quantitative (90-98%) and fast (<30 min) elution of proPalabras claves:Passive elution, Protein detection, Protein micropurification, SDS PAGE, Trace enrichmentAutores:Castellanos‐Serra L., Eugenio Hardy, Fernandez‐Patron C., Huerta V., Santana-Milián H.Fuentes:scopusMMP-2: Is too low as bad as too high in the cardiovascular system?
ReviewAbstract: Matrix metalloproteinase (MMP)-2 cleaves a broad spectrum of substrates, including extracellular matPalabras claves:heart, inflammation, Matrix metalloproteinase, metabolismAutores:Eugenio Hardy, Fernandez‐Patron C., Hardy-Sosa A.Fuentes:scopusIdentification of fibrinogen as a natural inhibitor of MMP-2
ArticleAbstract: Non-genetic MMP-2 insufficiency is a relatively unexplored condition which could be induced by pathoPalabras claves:Autores:Botto L.D., Eugenio Hardy, Fernandez‐Patron C., Haimour A., Maksymowych W.P., Sarker H.Fuentes:scopus