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Bioorganic Chemistry(1)
Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology(1)
Current Issues in Molecular Biology(1)
Drug Development Research(1)
European Journal of Medicinal Chemistry(1)
A novel synthetic peptide inspired on Lys49 phospholipase A<inf>2</inf> from Crotalus oreganus abyssus snake venom active against multidrug-resistant clinical isolates
ArticleAbstract: Currently, the evolving and complex mechanisms of bacterial resistance to conventional antibiotics aPalabras claves:Antibacterial activity, Biomimetic peptide, Phospholipase A 2, Snake venomAutores:Bruno Mendes, Fernandes P.A., Gomes P.A.D.C., José Rafael de Almeida, Lancellotti M., Marangoni S., Passos Ó., Ramos M.J., Saulo L. Silva, Vale N.Fuentes:scopusDissection of phospholipases A<inf>2</inf> reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria
ArticleAbstract: Cationic peptides bio-inspired by natural toxins have been recognized as an efficient strategy for tPalabras claves:Antimicrobial, Cationic, Cytotoxicity, Leishmanicidal activity, Snake venomAutores:Bruno Mendes, Carolina Proaño-Bolaños, Cristóbal Leonardo Domínguez-Borbor, Edgar A. Pinos-Tamayo, José Rafael de Almeida, Maria S. Peña-Carrillo, Miguel D.C.Fuentes:googlescopusHarnessing snake venom phospholipases A <inf>2</inf> to novel approaches for overcoming antibiotic resistance
ReviewAbstract: The emergence of antibiotic resistance drives an essential race against time to reveal new molecularPalabras claves:antibacterial peptides, antibiotic-resistant bacteria, Peptidomimetics, Phospholipase A 2, Snake venomAutores:Antonio L.V. Palacios, Bruno Mendes, Gomes P.A.D.C., José Rafael de Almeida, Ricardo S.P. Patiño, Saulo L. Silva, Teixeira C.A.S.Fuentes:googlescopusPeptides to tackle leishmaniasis: Current status and future directions
ReviewAbstract: Peptide-based drugs are an attractive class of therapeutic agents, recently recognized by the pharmaPalabras claves:Amastigote, Drug Discovery, Leishmania spp, Peptides, PromastigoteAutores:Alberto A. Robles-Loaiza, Alejandro Pinos-Tamayo, Alves C., Bruno Mendes, Edgar A. Pinos-Tamayo, Gomes P.A.D.C., José Rafael de Almeida, Teixeira C.A.S.Fuentes:googlescopusLessons from a Single Amino Acid Substitution: Anticancer and Antibacterial Properties of Two Phospholipase A<inf>2</inf>-Derived Peptides
ArticleAbstract: The membrane-active nature of phospholipase A2-derived peptides makes them potential candidates forPalabras claves:Agkistrodon, leucine, Membrane, Phenylalanine, Venom peptidesAutores:Alves C., Bruno Mendes, Fernandes P.A., Franchi G.C., Gomes P.A.D.C., José Rafael de Almeida, Lancellotti M., Passos Ó., Ramos M.J., Saulo L. Silva, Vale N.Fuentes:scopusTraditional and Computational Screening of Non-Toxic Peptides and Approaches to Improving Selectivity
ReviewAbstract: Peptides have positively impacted the pharmaceutical industry as drugs, biomarkers, or diagnostic toPalabras claves:hemolysis, IN SILICO, Machine learning, Peptides, ToxicityAutores:Alberto A. Robles-Loaiza, Bruno Mendes, Carolina Proaño-Bolaños, Edgar A. Pinos-Tamayo, Gomes P.A.D.C., José Rafael de Almeida, Josselyn A. Ortega-Pila, Plisson F., Teixeira C.A.S.Fuentes:scopusPotential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents
ArticleAbstract: Phospholipase A2 toxins present in snake venoms interact with biological membranes and serve as struPalabras claves:Leishmanicidal activity, Oligoarginine, peptide, PhospholipaseAutores:Bruno Mendes, Gadelha F.R., Gomes P.A.D.C., José Rafael de Almeida, Miguel D.C., Saulo L. Silva, Vale N.Fuentes:scopus