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Asymmetric pictet-spengler reactions: Synthesis of 1,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic) chimeras
ArticleAbstract: A preparatively simple diastereoselective synthesis of the amino acid chimera (1S,3S)-1,2,3,4-tetrahPalabras claves:amino acids, Cyclizations, Diastereoselectivity, heterocycles, QuinolinesAutores:Broxterman Q.B., Burger K., Duchateau A.L.L., Jan Spengler, Quaedflieg P.J.L.M., Schedel H., Sieler J.Fuentes:googlescopusAn efficient synthesis of N-phosphinoylmethylamino acids and some of their derivatives
ArticleAbstract: N-Phosphinoylmethylamino acid derivatives 11-18 are obtained in high yield on N-bromomethylation ofPalabras claves:Autores:Burger K., Jan SpenglerFuentes:googlescopusA new approach to N-methylaspartic, N-methylglutamic, and N-methyl-α- aminoadipic acid derivatives
ArticleAbstract: N-Methylaspartic acid derivatives and its homologues are obtained by a stereoconservative one-pot prPalabras claves:Hexafluoroacetone, N-Methyl- α-aminoadipic acid, N-Methylaspartic acid, N-Methylglutamic acid, N-Methylthiazol-4-yl-α-amino acidsAutores:Burger K., Jan SpenglerFuentes:scopusA novel protecting/activating strategy for β-hydroxy acids and its use in convergent peptide synthesis
ArticleAbstract: (Chemical Equation Presented) β-Hydroxy acids were reacted with hexafluoroacetone and carbodiimidesPalabras claves:Autores:Alberício F., Burger K., Jan Spengler, Royo M., Ruíz-Rodríguez J., Winter M., Yraola F.Fuentes:googlescopusCysteine-S-trityl a key derivative to prepare N-methyl cysteines
ArticleAbstract: S-Trt Cys are used as precursors for the synthesis of protected NMe-Cys. N-Methylation of Alloc-Cys(Palabras claves:Autores:Alberício F., Bayó-Puxan N., Jan Spengler, Marcucci E., Tulla-Puche J.Fuentes:googlescopusDomino reactions with fluorinated five-membered heterocycles - Syntheses of trifluoromethyl substituted butenolides and γ-ketoacids
ArticleAbstract: A new approach to trifluoromethyl substituted butenolides and their thioanalogues is described startPalabras claves:2-Fluoro-3-trifluoromethylfurans, 2-Fluoro-3-trifluoromethylthiophenes, Domino reactions, Trifluoromethyl substituted butenolides, α-Trifluoromethyl-γ-keto acidsAutores:Alberício F., Burger K., Fuchs A., Greif D., Hennig L., Jan SpenglerFuentes:googlescopusEfficient cysteine labelling of peptides with N-succinimidyl 4-[ <sup>18</sup>F]fluorobenzoate: Stability study and in vivo biodistribution in rats by positron emission tomography (PET)
ArticleAbstract: A rapid and high-yielding cysteine labelling of peptides has been observed with the specific labelliPalabras claves:Autores:Abad S., Alberício F., Gispert J.D., Herance J.R., Jan Spengler, Nolis P., Rojas S.Fuentes:googlescopusOrthogonally protected, carboxy-activated L-homoisoserine, 2-methyl-L-homoisoserine, and homoisocysteine derivatives. New building blocks for peptide and depsipeptide modification
ArticleAbstract: Starting from L-malic, L-citramalic, and rac. thiomalic acids routes to L-homoisoserine, 2-methyl-L-Palabras claves:Arndt-Eistert reaction, Azapeptides, Citramalic acid, Curtius rearrangement, Depsipeptide modification, Hexafluoroacetone, malic acid, Peptide modification, Thiomalic acid, Wolff rearrangement, α-Hydroxy acids, α-Mercapto acids, γ-Amino acidsAutores:Alberício F., Böttcher C., Burger K., Hennig L., Jan Spengler, Radics G.Fuentes:googlescopusIncorporation of the α-mercapto acid unit into peptides
ArticleAbstract: Incorporation of α-mercapto acid units into the backbone of potential drug candidates improves the mPalabras claves:Acylations, Dielectrophiles, Hexafluoroacetone, Peptides, Thiols, Thiomalic acidAutores:Alberício F., Burger K., Haas A., Jan Spengler, Pumpor K.Fuentes:googlescopusL-α-Methylhomoisoserine: A New Versatile Building Block for Peptide and Depsipeptide Modification
ArticleAbstract: An efficient access to L-α-methylhomoisoserine derivatives starting from L-citramalic acid is descriPalabras claves:Amino acid hydroxamates, Arndt-Eistert synthesis, Citramalic acid, Curtius rearrangement, Hexafluoroacetone, Wolff rearrangement, γ-amino-α-hydroxy-α -methylbutyric acidAutores:Burger K., El-Kousy S.M., Jan Spengler, Koksch B., Radics G.Fuentes:googlescopus