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Article(7)
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Antimicrobial Agents and Chemotherapy(4)
Journal of Medicinal Chemistry(1)
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4(1H)-quinolones with liver stage activity against Plasmodium berghei
ArticleAbstract: With the exception of primaquine, tafenoquine, and atovaquone, there are very few antimalarials thatPalabras claves:Autores:Cross R.M., Fabián E. Sáenz, Kyle D.E., Lacrue A.N., Manetsch R., Monastyrskyi A., Mutka T.S., Stein S., Udenze K.O.Fuentes:googlescopus4-(1H)-quinolones and 1,2,3,4-tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni
ArticleAbstract: Malaria kills approximately 1 million people a year, mainly in sub-Saharan Africa. Essential steps iPalabras claves:Autores:Cross R.M., Fabián E. Sáenz, Kyle D.E., Lacrue A.N., Maignan J.R., Manetsch R., Udenze K.O.Fuentes:googlescopusEvidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model
ArticleAbstract: The increasing prevalence in Southeast Asia of Plasmodium falciparum infections with delayed parasitPalabras claves:Autores:Cremers S., Fabián E. Sáenz, Fidock D.A., Henrich P.P., Kyle D.E., O'Brien C.Fuentes:googlescopusNovel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro
ArticleAbstract: New drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, wellPalabras claves:Autores:Fabián E. Sáenz, Kyle D.E., Mutka T.S., Oduola A.M.J., Udenze K.O.Fuentes:googlescopusOrally bioavailable 6-chloro-7-methoxy-4(1 H)-quinolones efficacious against multiple stages of plasmodium
ArticleAbstract: The continued proliferation of malaria throughout temperate and tropical regions of the world has prPalabras claves:Autores:Bathurst I., Burrows J.N., Charman S.A., Cross R.M., Fabián E. Sáenz, Flanigan D.L., Fronczek F.R., Guida W.C., Kyle D.E., Lacrue A.N., Maignan J.R., Manetsch R., Monastyrskyi A., Mutka T.S., Shackleford D.M., White K.L., Wojtas L.Fuentes:googlescopusQuinolone-3-diarylethers: A new class of antimalarial drug
ArticleAbstract: The goal for developing new antimalarial drugs is to find a molecule that can target multiple stagesPalabras claves:Autores:Angulo-Barturen I., Avery V.M., Bathurst I., Burrows J.N., Charman S.A., Cross R.M., Delves M.J., Duffy S., Fabián E. Sáenz, Ferrer S., Forquer I.P., Gamo F.J., Guy R.K., Herreros E., Jiménez-Díaz M.B., Kelly J.X., Kocken C.H.M., Kyle D.E., Lacrue A.N., Li Y., Manetsch R., Marfurt J., Mather M.W., Morrisey J.M., Mutka T.S., Nilsen A., Noviyanti R., Price R.N., Riscoe M.K., Ryan E., Sanz L.M., Sebayang B.F., Shackleford D.M., Siegl P., Sinden R.E., Steuten J., Vaidya A.B., White K.L., Winter R.W., Wirjanata G., Zeeman A.M.Fuentes:googlescopusThe transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands
ArticleAbstract: Malaria transmission depends on infective stages in the mosquito salivary glands. Plasmodium sporozoPalabras claves:Autores:Adams J.H., Balu B., Fabián E. Sáenz, Mendonca S.R., Smith J.Fuentes:googlescopus