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4(1H)-quinolones with liver stage activity against Plasmodium berghei
ArticleAbstract: With the exception of primaquine, tafenoquine, and atovaquone, there are very few antimalarials thatPalabras claves:Autores:Cross R.M., Fabián E. Sáenz, Kyle D.E., Lacrue A.N., Manetsch R., Monastyrskyi A., Mutka T.S., Stein S., Udenze K.O.Fuentes:googlescopus4-(1H)-quinolones and 1,2,3,4-tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni
ArticleAbstract: Malaria kills approximately 1 million people a year, mainly in sub-Saharan Africa. Essential steps iPalabras claves:Autores:Cross R.M., Fabián E. Sáenz, Kyle D.E., Lacrue A.N., Maignan J.R., Manetsch R., Udenze K.O.Fuentes:googlescopusClonal population expansion in an outbreak of Plasmodium falciparum on the northwest coast of Ecuador
ArticleAbstract: Background: Determining the source of malaria outbreaks in Ecuador and identifying remaining transmiPalabras claves:ECUADOR, MALARIA, Microsatellite markers, Outbreak, Plasmodium falciparumAutores:Castro L.E., Claudia A. Vera-Arias, Eileen Vélez-Álvarez, Fabián E. Sáenz, Gabriela Valenzuela, Lucchi N.W., Morton L.C., Okoth S.A., Udhayakumar V.Fuentes:scopusDiverse origin of Plasmodium falciparum in northwest Ecuador
ArticleAbstract: Background: Ecuador plans to eliminate malaria by 2020, and the country has already seen a decreasePalabras claves:ECUADOR, Genetic structure, MALARIA, microsatellites, Plasmodium falciparumAutores:Castro L.E., Claudia A. Vera-Arias, Fabián E. Sáenz, Gómez-Obando J.Fuentes:googlescopusGenotypes and phenotypes of resistance in Ecuadorian Plasmodium falciparum
ArticleAbstract: Background: Malaria continues to be endemic in the coast and Amazon regions of Ecuador. Clarifying cPalabras claves:ECUADOR, Genotypes, MALARIA, Phenotypes, Plasmodium falciparum, RESISTANCEAutores:Castro L.E., Claudia A. Vera-Arias, Fabián E. Sáenz, Gabriela Valenzuela, Rohrbach P., Valencia-Zamora J.Fuentes:googlescopusEvidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model
ArticleAbstract: The increasing prevalence in Southeast Asia of Plasmodium falciparum infections with delayed parasitPalabras claves:Autores:Cremers S., Fabián E. Sáenz, Fidock D.A., Henrich P.P., Kyle D.E., O'Brien C.Fuentes:googlescopusTargeted disruption of maebl in Plasmodium falciparum
ArticleAbstract:Palabras claves:Erythrocyte binding protein, Invasion assays, MAEBL, MALARIA, Plasmodium falciparumAutores:Adams J.H., Balu B., Blair P., Cowman A., Fabián E. Sáenz, Fu J., Reed M., Singh N.Fuentes:googlescopusThe transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands
ArticleAbstract: Malaria transmission depends on infective stages in the mosquito salivary glands. Plasmodium sporozoPalabras claves:Autores:Adams J.H., Balu B., Fabián E. Sáenz, Mendonca S.R., Smith J.Fuentes:googlescopusNovel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro
ArticleAbstract: New drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, wellPalabras claves:Autores:Fabián E. Sáenz, Kyle D.E., Mutka T.S., Oduola A.M.J., Udenze K.O.Fuentes:googlescopusOrally bioavailable 6-chloro-7-methoxy-4(1 H)-quinolones efficacious against multiple stages of plasmodium
ArticleAbstract: The continued proliferation of malaria throughout temperate and tropical regions of the world has prPalabras claves:Autores:Bathurst I., Burrows J.N., Charman S.A., Cross R.M., Fabián E. Sáenz, Flanigan D.L., Fronczek F.R., Guida W.C., Kyle D.E., Lacrue A.N., Maignan J.R., Manetsch R., Monastyrskyi A., Mutka T.S., Shackleford D.M., White K.L., Wojtas L.Fuentes:googlescopus