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CTLA4 message reflects pathway disruption in monogenic disorders and under therapeutic blockade
ReviewAbstract: CTLA-4 is essential for immune tolerance. Heterozygous CTLA4 mutations cause immune dysregulation evPalabras claves:CTLA4, immunotherapy, Ipilimumab, LRBA, mRNAAutores:Baxter R.M., Dutmer C.M., Hsieh E.W.Y., Jordan M.B., Josselyn E. Garcia-Perez, Kong D.S., McCarter M., Routes J.M., Tobin R., Verbsky J.Fuentes:scopusGenetic Architecture of Adaptive Immune System Identifies Key Immune Regulators
ArticleAbstract: The immune system is highly diverse, but characterization of its genetic architecture has lagged behPalabras claves:adaptive immune system, association, autoimmunity, Genetics, Genome-wide association, immune phenotype, susceptibilityAutores:Boeckxstaens G., Bowness P., Chen L., Dooley J., Dubois B., Goris A., Hilven K., Humblet-Baron S., Josselyn E. Garcia-Perez, Lagou V., Liston A., Mallants K., Moisse M., Prezzemolo T., Smets I., Van Damme P., Van Horebeek L., Vandebergh M.Fuentes:scopus