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Analysis of HIF-prolyl hydroxylases binding to substrates
ArticleAbstract: Hypoxia inducible transcription factors (HIF) are mainly regulated by a group of proline hydroxylasePalabras claves:EGLN, HIF, Hypoxia, PhD, Proline-hydroxylation, VHLAutores:Cuevas Y., Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A., Vitón M.Fuentes:scopusCD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
ArticleAbstract: CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognatePalabras claves:CD69, HIF-1α, Hypoxia, tumor microenvironment, tumor-infiltrating lymphocytes (TILs)Autores:Aragonés J., Aznar M.Á., Azpilikueta A., Bolaños E., de la Fuente H., Etxeberria I., Garasa S., Labiano S., Maiso P., Manuel Ortiz de Landázuri, Meléndez-Rodríguez F., Melero I., Molina C., Palazón A., Sánchez-Paulete A.R., Sánchez‐Madrid F., Teijeira A.Fuentes:scopusGeneration of a highly sensitive reporter plasmid for the detection of the transcripcional response to hypoxia
ArticleAbstract: Decreased oxygen supply to the tissues at both systemic and local level induces a genic program whicPalabras claves:HIF-1α, Hypoxia, transcription factorsAutores:Alfranca A., Aragonés J., Manuel Ortiz de Landázuri, Temes E., Vara A.Fuentes:scopusMyeloid hypoxia-lnducible factors in inflammatory diseases
ArticleAbstract: Hypoxia inducible factors (HIFI and HIF2) have emerged as central regulators of the activity of myelPalabras claves:Hypoxia, Hypoxia-inducible factor (HIF), inflammation, MacrophagesAutores:Acosta-Lborra B., Aragonés J., Elorza A., Manuel Ortiz de LandázuriFuentes:scopusIdentification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
ArticleAbstract: HIFs [hypoxia-inducible (transcription) factors] are essential for the induction of an adaptive genePalabras claves:EGL nine homologue (EGLN), Hypoxia, Hypoxia-inducible factor (HIF), Oxygen-degradation domain (ODD), Proline hydroxylase domain (PHD), Von Hippel-Lindau protein (VHL protein)Autores:Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A., Villar D.Fuentes:scopusReduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions
ArticleAbstract: The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subseqPalabras claves:adhesion, antioxidant, flow, Hypoxia, NeutrophilAutores:Aragonés J., Del Pozo M.A., Luscinskas F.W., Manuel Ortiz de Landázuri, Montoya M.C.Fuentes:scopusRole of diacylglycerol induced by hypoxia in the regulation of HIF-1α activity
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) is a critical transcription factor for the adaptation to loweredPalabras claves:Diacylglycerol, HIF-1, Hypoxia, Lipid second messengers, Phosphatidic acid, Protein regulation, signal transductionAutores:Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., Olmos G., Temes E.Fuentes:scopus