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Article(5)
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Current Topics in Medicinal Chemistry(1)
European Journal of Medicinal Chemistry(1)
Journal of Ethnopharmacology(1)
PLoS ONE(1)
Anti-inflammatory activity and cheminformatics analysis of new potent 2-substituted 1-methyl-5-nitroindazolinones
ArticleAbstract: After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroiPalabras claves:Anti-inflammatory compound, Nitroindazolinones, SARANEA software, Structure-activity relationship, TPA-induced mouse ear edema, zebrafishAutores:Andújar I., Arán V.J., Crawford A.D., De Witte P.A.M., Díaz-Mendoza C., Giner R.M., Manjarrez G., María Lorena Cordero-Maldonado, Pérez-Jiménez F., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:scopusAnti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
ArticleAbstract: Ethnopharmacological relevance: Epilepsy is one of the major chronic diseases that does not have a cPalabras claves:Epilepsy, Pleiocarpamine, Rauverine H, Rauvolfia caffra, zebrafishAutores:Chen W., Chipiti T., Crawford A.D., Enslin G.M., María Lorena Cordero-Maldonado, Sandasi M., Van Heerden F.R., Veale C.G.L., Viljoen A.M.Fuentes:scopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusOptimization and Pharmacological Validation of a Leukocyte Migration Assay in Zebrafish Larvae for the Rapid In Vivo Bioactivity Analysis of Anti-Inflammatory Secondary Metabolites
ArticleAbstract: Over the past decade, zebrafish (Danio rerio) have emerged as an attractive model for in vivo drug dPalabras claves:Autores:Crawford A.D., De Witte P.A.M., Esguerra C.V., Isabel María Wilches Arizabala, María Lorena Cordero-Maldonado, Siverio-Mota D., Vicet-Muro L., Wilches IsabelFuentes:rraaescopusOptimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid In vivo bioactivity analysis of anti-inflammatory secondar metabolitesy
ArticleAbstract: Over the past decade, zebrafish (Danio rerio) have emerged as an attractive model for in vivo drug dPalabras claves:Farmacologia, LEUCOCITOS, PEZ CEBRAAutores:Alexander D. Crawford, Camila V. Esguerra, Dany Siverio Mota, Isabel María Wilches Arizábala, Liliana Vicet Muro, María Lorena Cordero-Maldonado, Peter A. M. Witte, deFuentes:rraae