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Journal of Ethnopharmacology(2)
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scopus(8)
Anti-inflammatory activity and cheminformatics analysis of new potent 2-substituted 1-methyl-5-nitroindazolinones
ArticleAbstract: After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroiPalabras claves:Anti-inflammatory compound, Nitroindazolinones, SARANEA software, Structure-activity relationship, TPA-induced mouse ear edema, zebrafishAutores:Andújar I., Arán V.J., Crawford A.D., De Witte P.A.M., Díaz-Mendoza C., Giner R.M., Manjarrez G., María Lorena Cordero-Maldonado, Pérez-Jiménez F., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:scopusAnti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
ArticleAbstract: Ethnopharmacological relevance: Epilepsy is one of the major chronic diseases that does not have a cPalabras claves:Epilepsy, Pleiocarpamine, Rauverine H, Rauvolfia caffra, zebrafishAutores:Chen W., Chipiti T., Crawford A.D., Enslin G.M., María Lorena Cordero-Maldonado, Sandasi M., Van Heerden F.R., Veale C.G.L., Viljoen A.M.Fuentes:scopusGender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies
ArticleAbstract: Public transcriptomic studies have shown that several genes display pronounced gender differences inPalabras claves:Alzheimer’s disease, Gender differences, Tau, Tauopathies, transcriptomics, zebrafishAutores:Antony P., Buttini M., Crawford A.D., Forster J.I., Garcia P., Glaab E., Köglsberger S., María Lorena Cordero-MaldonadoFuentes:scopusEvaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays
ArticleAbstract: Ethnopharmacological relevance: In South Africa, medicinal plants have a history of traditional use,Palabras claves:Cotyledon orbiculata, Lobostemon fruticosus, Pro-angiogenesis, Scabiosa columbaria, Traditional medicine, Wound healing, zebrafishAutores:Crawford A.D., Hattingh A.C., Katerere D., Koekemoer T.C., María Lorena Cordero-Maldonado, Mhlongo F., Sandasi M., van de Venter M., Viljoen A.M.Fuentes:scopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusNew insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome
ArticleAbstract: Objective: To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period)Palabras claves:Dravet syndrome, epileptogenesis, fenfluramine, Sodium channel, zebrafishAutores:Brattespe J., Esguerra C.V., Gawel K., Grzyb K., Heintz S., María Lorena Cordero-Maldonado, Martina S., Poovathingal S.K., Satheesh S.V., Skupin A., Suster M., Tiraboschi E., van der Ent W., Xu J.Fuentes:scopusPhenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency
ArticleAbstract: Mutations in ATP13A2 (PARK9) are causally linked to the rare neurodegenerative disorders Kufor-RakebPalabras claves:ATP13A2, budding yeast, drug screening, Heavy Metals, zebrafishAutores:Crawford A.D., Heins-Marroquin U., Jung P.P., Linster C.L., María Lorena Cordero-MaldonadoFuentes:scopusl-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain
ArticleAbstract: Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protPalabras claves:Calcium signaling, HT22 cells, isoaspartyl, protein repair, zebrafishAutores:Clarke S.G., Conrotte J.F., Crawford A.D., Linster C.L., María Lorena Cordero-Maldonado, Martins T.G., Moein M., Skupin A., Soliman R., Warmack R.A.Fuentes:scopus