Mostrando 3 resultados de: 3
Subtipo de publicación
Article(3)
Área temáticas
Farmacología y terapéutica(3)
Química y ciencias afines(2)
Bioquímica(1)
Química orgánica(1)
Objetivos de Desarrollo Sostenible
ODS 3: Salud y bienestar(3)
ODS 9: Industria, innovación e infraestructura(3)
Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusIntegration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products
ArticleAbstract: Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovPalabras claves:Autores:Bohni N., Crawford A.D., De Witte P.A.M., Esguerra C.V., Kamuhabwa A.R., Maes J., Marcourt L., María Lorena Cordero-Maldonado, Moshi M.J., Munck S., Siverio-Mota D., Wolfender J.L.Fuentes:rraaescopusIntegration of microfractionation, qNMR and zebrafish screening for the In vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products
ArticleAbstract: Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovPalabras claves:BIOENSAYO, PEZ CEBRAAutores:Alexander D. Crawford, Appolinary R. Kamuhabwa, Camila V. Esguerra, Dany Siverio Mota, Jan Maes, Jean-Luc Wolfender, Laurence Marcourt, Mainen J. Moshi, María Lorena Cordero-Maldonado, Nadine Bohni, Peter A. M. Witte, de, Sebastian MunckFuentes:rraae