Mostrando 10 resultados de: 14
Filtros aplicados
Publisher
PLoS ONE(3)
Bioorganic and Medicinal Chemistry Letters(1)
Brain(1)
Brain Communications(1)
Current Topics in Medicinal Chemistry(1)
Área temáticas
Farmacología y terapéutica(7)
Fisiología humana(4)
Química y ciencias afines(4)
Microorganismos, hongos y algas(3)
Enfermedades(2)
Área de conocimiento
Farmacología(5)
Descubrimiento de fármacos(3)
Biología(2)
Bioquímica(2)
Biotecnología(2)
2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes
ArticleAbstract: The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liPalabras claves:2-Octadecynoic acid, Acetylenic fatty acids, Blood stage, Liver stage, MALARIA, plasmodium, Type II fatty acid synthaseAutores:Andricopulo A.D., Bwalya A.G., Carballeira N.M., Crawford A.D., Guido R.V.C., Itoe M.A., Kaiser M., María Lorena Cordero-Maldonado, Mota M.M., Tasdemir D.Fuentes:scopusA phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling
ArticleAbstract: Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation andPalabras claves:Autores:Clements C., Crawford A.D., De Witte P.A.M., Edrada-Ebel R., Esguerra C.V., Gebruers E., Gray A.I., Harvey A.L., María Lorena Cordero-MaldonadoFuentes:rraaescopusAnti-inflammatory activity and cheminformatics analysis of new potent 2-substituted 1-methyl-5-nitroindazolinones
ArticleAbstract: After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroiPalabras claves:Anti-inflammatory compound, Nitroindazolinones, SARANEA software, Structure-activity relationship, TPA-induced mouse ear edema, zebrafishAutores:Andújar I., Arán V.J., Crawford A.D., De Witte P.A.M., Díaz-Mendoza C., Giner R.M., Manjarrez G., María Lorena Cordero-Maldonado, Pérez-Jiménez F., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:scopusAnti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
ArticleAbstract: Ethnopharmacological relevance: Epilepsy is one of the major chronic diseases that does not have a cPalabras claves:Epilepsy, Pleiocarpamine, Rauverine H, Rauvolfia caffra, zebrafishAutores:Chen W., Chipiti T., Crawford A.D., Enslin G.M., María Lorena Cordero-Maldonado, Sandasi M., Van Heerden F.R., Veale C.G.L., Viljoen A.M.Fuentes:scopusCHD2 variants are a risk factor for photosensitivity in epilepsy
ArticleAbstract: Photosensitivity is a heritable abnormal cortical response to flickering light, manifesting as partiPalabras claves:Eyelid myoclonia with absences, Photosensitive, SeizureAutores:Afrikanova T., Berkovic S.F., Boustred C., Cantonetti L., Capovilla G., Chinthapalli V.K., Coppola A., Covanis A., Crawford A.D., De Kovel C.G.F., Del Gaudio L., Drury S., Esguerra C.V., Galizia E.C., Helbig I., Jacmin M., Jocic-Jakubi B., Koeleman B.P.C., Krause R., Lehesjoki A.E., Lench N., Lerche H., Leu C., María Lorena Cordero-Maldonado, Martins T.G., Mefford H.C., Moller R.S., Muhle H., Mullen S.A., Myers C.T., Nürnberg P., Palotie A., Parisi P., Pendziwiat M., Piccioli M., Ruppert A.K., Sadleir L.G., Sander T., Scheffer I.E., Schneider A.L., Schubert J., Sisodiya S.M., Stephani U., Striano S., Thiele H., Trenité D.G.A.K.N., Veggiotti P.Fuentes:scopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusIntegration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products
ArticleAbstract: Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovPalabras claves:Autores:Bohni N., Crawford A.D., De Witte P.A.M., Esguerra C.V., Kamuhabwa A.R., Maes J., Marcourt L., María Lorena Cordero-Maldonado, Moshi M.J., Munck S., Siverio-Mota D., Wolfender J.L.Fuentes:rraaescopusIntegration of microfractionation, qNMR and zebrafish screening for the In vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products
ArticleAbstract: Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovPalabras claves:BIOENSAYO, PEZ CEBRAAutores:Alexander D. Crawford, Appolinary R. Kamuhabwa, Camila V. Esguerra, Dany Siverio Mota, Jan Maes, Jean-Luc Wolfender, Laurence Marcourt, Mainen J. Moshi, María Lorena Cordero-Maldonado, Nadine Bohni, Peter A. M. Witte, de, Sebastian MunckFuentes:rraaeNew insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome
ArticleAbstract: Objective: To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period)Palabras claves:Dravet syndrome, epileptogenesis, fenfluramine, Sodium channel, zebrafishAutores:Brattespe J., Esguerra C.V., Gawel K., Grzyb K., Heintz S., María Lorena Cordero-Maldonado, Martina S., Poovathingal S.K., Satheesh S.V., Skupin A., Suster M., Tiraboschi E., van der Ent W., Xu J.Fuentes:scopusOptimization and Pharmacological Validation of a Leukocyte Migration Assay in Zebrafish Larvae for the Rapid In Vivo Bioactivity Analysis of Anti-Inflammatory Secondary Metabolites
ArticleAbstract: Over the past decade, zebrafish (Danio rerio) have emerged as an attractive model for in vivo drug dPalabras claves:Autores:Crawford A.D., De Witte P.A.M., Esguerra C.V., Isabel María Wilches Arizabala, María Lorena Cordero-Maldonado, Siverio-Mota D., Vicet-Muro L., Wilches IsabelFuentes:rraaescopus