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Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis
ArticleAbstract: Consensus strategy was proved to be highly efficient in the recognition of gene-disease association.Palabras claves:Autores:Alejandro Cabrera-Andrade, Andrés López-Cortés, Cesar Paz-y-Miño, Eduardo Tejera, González‐díaz H., Munteanu C.R., Sierra A.P., Stephen Jones Barigye, Yunierkis Perez-CastilloFuentes:googlescopusComputational identification of chemical compounds with potential anti-Chagas activity using a classification tree
ArticleAbstract: Chagas disease is endemic to 21 Latin American countries and is a great public health problem in thaPalabras claves:Anti-chagasic action, Chagas disease, classification tree, TRYPANOSOMA CRUZI, Virtual ScreeningAutores:Garit J., Pérez-Doñate V., Pérez-Giménez F., Pham-The H., Stephen Jones Barigye, Torrens F.Fuentes:scopusComputational modelling of the antischistosomal activity for neolignan derivatives based on the MIA-SAR approach
ArticleAbstract: Theoretical models for exploring the antischistosomal activity of a dataset of 18 synthetic neolignaPalabras claves:HCA, MIA-SAR, PCa, PLS-DA, Schistosoma mansoniAutores:da Mota E.G., Duarte M.H., Freitas M.P., Stephen Jones BarigyeFuentes:scopusCellular estimation Gaussian algorithm for continuous domain
ArticleAbstract: Optimization algorithms are important in problems of pattern recognition and artificial intelligencePalabras claves:Cellular EDA, GAUSSIAN networks, Learning, Probabilistic graph modelAutores:Quintana J.M., Rodríguez-González A.Y., Stephen Jones Barigye, Yoan Martínez LópezFuentes:scopusAntiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones
ArticleAbstract: Protozoan parasites have been one of the most significant public health problems for centuries and sPalabras claves:Antimalarial, Antiprotozoan database, Antitoxoplasma, antitrichomonas, Antitrypanosomal, classification model, Cytotoxicity, In silico study, In vitro assay, Leishmanicide, Machine learning-based QSAR, Non-stochastic and stochastic linear indices, ToMoCoMD-CARDD softwareAutores:Arán V.J., Cabrera-Serra M.G., Chicharro R., García-Domenech R., García-Sánchez R.N., García-Trevijano J.A.E., Gómez-Barrio A., Ibarra-Velarde F., López-Arencibia A., Lorenzo-Morales J., Machado-Tugores Y., Martín-Navarro C., Martínez-Fernández A.R., Martins Alho M.A., Meneses-Marcel A., Mondragón M., Mondragón R., Montero-Torres A., Nogal-Ruiz J.J., Pérez-Giménez F., Piñero J.E., Rivera N., Rolón M.S., Stephen Jones Barigye, Tytgat J., Vega M.C., Yovani Marrero-PonceFuentes:scopusIdentification of NLRP3<sup>PYD</sup> Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity
ArticleAbstract: Inflammasomes are multiprotein complexes that represent critical elements of the inflammatory responPalabras claves:Inflammasome inhibitors, NLRP3, PYD, Pyroptosis, screening, Split-luciferaseAutores:Fernández-Pérez I., Ghafary S.M., Gozalbes R., Hosseinkhani S., Karami F., Lotfollahzadeh S., Nikkhah M., Orzáez M., Sancho M., Serrano-Candelas E., Soriano-Teruel P.M., Stephen Jones BarigyeFuentes:scopusDerivatives in discrete mathematics: a novel graph-theoretical invariant for generating new 2/3D molecular descriptors. I. Theory and QSPR application.
ArticleAbstract: In this report, we present a new mathematical approach for describing chemical structures of organicPalabras claves:Autores:López Y.M., Santiago O.M., Stephen Jones Barigye, Torrens F., Yovani Marrero-PonceFuentes:scopusDrug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening
ArticleAbstract: Aim: Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence ofPalabras claves:antitrichomonas, QSAR, QuBiLS-MAS, ToMoCoMD-CARDD, Trichomonas vaginalisAutores:Arán-Redó V.J., César R. García-Jacas, Enrique Terán, García-Trevijano J.A.E., Gómez-Barrio A., Ibáñez-Escribano A., Machado-Tugores Y., Meneses-Marcel A., Nogal-Ruiz J.J., Stephen Jones Barigye, Yovani Marrero-PonceFuentes:scopusOncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine
ArticleAbstract: Breast cancer (BC) is the leading cause of cancer-related death among women and the most commonly diPalabras claves:Autores:Alejandro Cabrera-Andrade, Andrés López-Cortés, Cesar Paz-y-Miño, Eduardo Tejera, González‐díaz H., Munteanu C.R., SANTIAGO XAVIER GUERRERO JIJÓN, Sierra A.P., Stephen Jones Barigye, Yunierkis Perez-CastilloFuentes:googlescopusUndersampling: case studies of flaviviral inhibitory activities
ArticleAbstract: Abstract: Imbalanced datasets, comprising of more inactive compounds relative to the active ones, arPalabras claves:Dengue Virus, Information index, Support Vector Machine, Undersampling, West nile virus, Zika VirusAutores:García-De La Vega J.M., Garit J., Stephen Jones BarigyeFuentes:scopus