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A multi-objective approach for anti-osteosarcoma cancer agents discovery through drug repurposing
ArticleAbstract: Osteosarcoma is the most common type of primary malignant bone tumor. Although nowadays 5-year surviPalabras claves:Drug repositioning, Machine learning, Multi-objective model, Osteosarcoma, Virtual ScreeningAutores:Alejandro Cabrera-Andrade, Andrés López-Cortés, Eduardo Tejera, Gabriela Fernanda Jaramillo-Koupermann, González‐díaz H., Munteanu C.R., Sierra A.P., Yunierkis Perez-CastilloFuentes:scopusCharacterization of Ancestral Origin of Cystic Fibrosis of Patients with New Reported Mutations in CFTR
ArticleAbstract: The incidence of cystic fibrosis (CF) and the frequency of the variants reported for CFTR depend onPalabras claves:Autores:, Alexandra Patricia Guevara, Andrés López-Cortés, Andy Pérez-Villa, Cesar Paz-y-Miño, Isaac Armendáriz-Castillo, Jennyfer García, Jennyfer M. García-Cárdenas, Juan Carlos Ruiz-Cabezas, Paola E. Leone, Santiago Xavier Guerrero, Verónica YumicebaFuentes:googlescopusClinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review
ReviewAbstract: Coronaviruses are an extensive family of viruses that can cause disease in both animals and humans.Palabras claves:CORONAVIRUS, covid-19, pandemic, Review, SARS-COV-2Autores:Ana María Gómez-Jaramillo, Andrés López-Cortés, Carlos Barba-Ostria, Cevallos-Robalino D., Claire Muslin, Esteban Ortiz-Prado, Gadian N., Hector Daniel Toalombo Guaman, Hugo Sanches-SanMiguel, Katherine Simbaña-Rivera, Lenin Gómez-Barreno, Linda P. Guamán, Luis Javier Unigarro, Nikolaos C. Kyriakidis, Rasa Zalakeviciute, Rubio-Neira M.Fuentes:googlescopusFrequency of polymorphisms pro198leu in GPX-1 gene and ile58thr in MnSOD gene in the altitude ecuadorian population with bladder cancer
ArticleAbstract: Bladder cancer represents 8% of all malignancies diagnosed in men and 3% in women. The risk factorsPalabras claves:bladder cancer, GPX-1, Ile58thr, MnSOD, Pro198leuAutores:Alejandro Cabrera-Andrade, Andrés López-Cortés, Castro B., Cesar Paz-y-Miño, María José G. Muñoz, María-Eugenia Sánchez, Palacios A., Paz-y-Miño N.Fuentes:googlescopusGene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis
ArticleAbstract: Consensus strategy was proved to be highly efficient in the recognition of gene-disease association.Palabras claves:Autores:Alejandro Cabrera-Andrade, Andrés López-Cortés, Cesar Paz-y-Miño, Eduardo Tejera, González‐díaz H., Munteanu C.R., Sierra A.P., Stephen Jones Barigye, Yunierkis Perez-CastilloFuentes:googlescopusGenes involved in damage response caused by UV radiation in Ecuadorian population of different altitude regions
ArticleAbstract: Ecuador has various regions at different altitudes. It is known that at high altitudes, organisms exPalabras claves:altitude, ECUADOR, UV radiation, XPC, XPD, XPGAutores:, Alexandra Patricia Guevara, Andrés López-Cortés, Andy Pérez-Villa, Cesar Paz-y-Miño, Isaac Armendáriz-Castillo, Jennyfer García, Jennyfer M. García-Cárdenas, Paola E. Leone, Santiago Xavier Guerrero, Verónica YumicebaFuentes:googlescopusIn silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19
ArticleAbstract: Background: There is pressing urgency to identify therapeutic targets and drugs that allow treatingPalabras claves:artificial neural networks, covid-19, drug repurposing, Immune system, single-cell RNA sequencingAutores:, Adriana Granizo-Martínez, Alejandro Cabrera-Andrade, Alexandra Patricia Guevara, Ana María Gómez-Jaramillo, Andreina Quevedo, Andrés López-Cortés, Ángela León-Cáceres, Carlos Barba-Ostria, Cesar Paz-y-Miño, Cevallos-Robalino D., Eduardo Tejera, Esteban Ortiz-Prado, Jennyfer M. García-Cárdenas, Jhommara Bautista, Katherine Simbaña-Rivera, Lourdes Puig San Andrés, Moreno S., Munteanu C.R., Nikolaos C. Kyriakidis, Pérez-M G., Proaño-Castro C., Quiñones L.A., Santiago Xavier Guerrero, Varela N.M., Yunierkis Perez-CastilloFuentes:scopusEvaluation of ancestral membership proportions and genotype distribution in the perception of Umami taste in Ecuadorian mestizos
ArticleAbstract: Genetic variation to flavor perception contributes the population differentiation, where the T allelPalabras claves:ECUADOR, Taste perception, UmamiAutores:, Alejandro Cabrera-Andrade, Alexandra Patricia Guevara, Andrés López-Cortés, Cesar Paz-y-Miño, D. A. González, Jennyfer García, Jennyfer M. García-Cárdenas, Paola E. LeoneFuentes:googlescopusIntegrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins
ArticleAbstract: More women are diagnosed with breast cancer (BC) than any other type of cancer. Although large-scalePalabras claves:Breast Cancer, cancer driver genes, in silico analysis, RBPsAutores:Andrea Jácome-Alvarado, Andrés López-Cortés, Andy Pérez-Villa, INDACOCHEA A., Isaac Armendáriz-Castillo, Jennyfer García, Jennyfer M. García-Cárdenas, Santiago Xavier GuerreroFuentes:googlescopusMolecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy
ReviewAbstract: The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuPalabras claves:recessive genetic disease, SMN1, SMN2, spinal muscular atrophyAutores:Andrés López-Cortés, Echeverría-Garcés G., Ramos-Medina M.J.Fuentes:googlescopus