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A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications
ArticleAbstract: Streptomyces clavuligerus is a Gram-positive bacterium that is a high producer of secondary metaboliPalabras claves:Antimicrobial peptide, Horizontal gene transfer, Hymenoptera, pSCL4, Streptomyces clavuligerus ATCC 27064Autores:Daniela Santander-Gordón, Eduardo Tejera, Sebastián Ayala-Ruano, Vinicio Danilo Armijos-Jaramillo, Yunierkis Perez-CastilloFuentes:googlescopusCompScore: Boosting Structure-Based Virtual Screening Performance by Incorporating Docking Scoring Function Components into Consensus Scoring
ArticleAbstract: Consensus scoring has become a commonly used strategy within structure-based virtual screening (VS)Palabras claves:Autores:Aminael Sánchez-Rodríguez, Borges F., Eduardo Tejera, Karina Beatríz Jimenes-Vargas, Mario González-Rodríguez, Maykel Cruz-Monteagudo, Natalia Dias Soeiro Cordeiro M., Stellamaris Sotomayor-Burneo, Vinicio Danilo Armijos-Jaramillo, Yunierkis Perez-CastilloFuentes:scopusAnalysis of DNA Polymerases Reveals Specific Genes Expansion in Leishmania and Trypanosoma spp.
ArticleAbstract: Leishmaniasis and trypanosomiasis are largely neglected diseases prevailing in tropical and subtropiPalabras claves:DNA polymerases, DNA repair, gene amplification, genome stability, translesion synthesis, trypanosomatidsAutores:ANA MARÍA POVEDA GABALDÓN, Miguel Angel Méndez, Vinicio Danilo Armijos-JaramilloFuentes:googlescopusCanonical or noncanonical? Structural plasticity of serine protease-binding loops in Kunitz-STI protease inhibitors
ArticleAbstract: The Kunitz-Soybean Trypsin Inhibitor (Kunitz-STI) family is a large family of proteins with most ofPalabras claves:canonical inhibitors, Kunitz, noncanonical inhibitors, protease inhibitors, serine proteaseAutores:Berry C., Eduardo Tejera, Pons T., Vinicio Danilo Armijos-Jaramillo, Yasel GuerraFuentes:googlescopusAnálisis evolutivo de retrovirus endógenos en mamíferos a partir del estudio comparado de secuencias
Bachelor ThesisAbstract: La placentación es un proceso de vital importancia durante la formación del feto, la comprensión dePalabras claves:Genetica, ORTOLOGÍA, PLACENTAAutores:Vinicio Danilo Armijos-Jaramillo, Wilde Agustín Ocaña EscobarFuentes:rraaeEnsemble-based modeling of chemical compounds with antimalarial activity
ArticleAbstract: Background: Malaria or Paludism is a tropical disease caused by parasites of the Plasmodium genre anPalabras claves:Antimalarial activity, Ensemble modeling, Genetic Algorithms, Majority vote, Malaria disease, QSARAutores:Benfenati E., Borges F., Caballero-Alfonso A.Y., Eduardo Tejera, Maykel Cruz-Monteagudo, Natalia Dias Soeiro Cordeiro M., Vinicio Danilo Armijos-Jaramillo, Yunierkis Perez-CastilloFuentes:scopusEvolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes
ArticleAbstract: Background. Endogenous retroviruses (ERVs) are the result of the integration of retroviruses into hoPalabras claves:Clinical variants, ERVs, EVOLUTION, Primates, transcription factorsAutores:Agustín Ocaña, Carmen López-Cruz, Eduardo Tejera, Melissa Calero-Layana, Vinicio Danilo Armijos-JaramilloFuentes:scopusSARS-CoV-2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stability
ArticleAbstract: The emergence of SARS-CoV-2 has resulted in nearly 1,280,000 infections and 73,000 deaths globally sPalabras claves:ACE2, CORONAVIRUS, molecular dynamics, positive selection, purifying selection, SARS-COV-2, Spike proteinAutores:Claire Muslin, Justin Yeager, Vinicio Danilo Armijos-Jaramillo, Yunierkis Perez-CastilloFuentes:googlescopusMultioutput Perturbation-Theory Machine Learning (PTML) Model of ChEMBL Data for Antiretroviral Compounds
ArticleAbstract: Retroviral infections, such as HIV, are, until now, diseases with no cure. Medicine and pharmaceuticPalabras claves:antiretroviral compounds, BIG DATA, CHEMBL, Machine learning, perturbation theoryAutores:Eduardo Tejera, Emilia Vásquez-Domínguez, González‐díaz H., Vinicio Danilo Armijos-JaramilloFuentes:googlescopusShadowcaster: Compositional methods under the shadow of phylogenetic models to detect horizontal gene transfers in prokaryotes
ArticleAbstract: Horizontal gene transfer (HGT) plays an important role for evolutionary innovations within prokaryotPalabras claves:Horizontal gene transfer, Hybrid approach, Implicit phylogenetic model, Parametric methodAutores:Agüero-Chapin G., Aminael Sánchez-Rodríguez, Antunes A., Daniela Sánchez-Soto, Eduardo Tejera, Vinicio Danilo Armijos-Jaramillo, Yunierkis Perez-CastilloFuentes:scopus