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4th ESPT Conference: Pharmacogenomics and personalized medicine - Research progress and clinical implementation
ArticleAbstract: The Fourth European Society of Pharmacogenomics and Personalized Therapy biennial conference was orgPalabras claves:clinical implementation, ESPT conference, personalized medicine, PharmacogenomicsAutores:Adrián LLerena, Ansari M., Cascorbi I., Drago F., Gozzo L., Ingelman-Sundberg M., Katsila T., Manolopoulos V.G., Marc J., Marchetti P., Meyer U.A., Mlakar V., Nofziger C., Paulmichl M., Pearson E., Re M.D., Simmaco M., Sipeky C., Stanković S., Suarez-Kurtz G., Van Schaik R.H.N.Fuentes:scopus4th ESPT summer school: Precision medicine and personalised health
Conference ObjectAbstract: In September 2018, the European Society of Pharmacogenomics and Personalised Therapy (ESPT), with thPalabras claves:Autores:Adrián LLerena, Amstutz U., Ansari M., Cascorbi I., Manolopoulos V.G., Marc J., Meier-Abt P., Meyer U.A., Mlakar V., Simmaco M., Sipeky C., Stanković S., Van Schaik R.H.N., Visvikis-Siest S.Fuentes:scopusA Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy
OtherAbstract:Palabras claves:Autores:Adrián LLerena, Bishop J.R., Bousman C.A., Caudle K.E., Gaedigk A., Gammal R.S., Hicks J.K., Klein T.E., Leeder J.S., Muller D.J., Ramsey L.B., Sangkuhl K., Scott S.A., Skaar T.C.Fuentes:scopusA combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances
ArticleAbstract: This study examined, for the first time, whether a high CYP2D6-CYP2C19 metabolic capacity combinatioPalabras claves:Autores:Adrián LLerena, Blasco-Fontecilla H., Courtet P., Delgado A., Guillaume S., Jaussent I., Naranjo M.E.G., Penãs-Lledó E.M.Fuentes:scopusA rapid and simple LC-MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity
ArticleAbstract: Background: The analytical method here reported for the CEIBA cocktail approach has been developed aPalabras claves:Autores:Adrián LLerena, de Andrés F., Sosa-Macías M.G.Fuentes:scopusCharacterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: Pharmacogenetic implications
ArticleAbstract: CYP2D6 codes for a protein that is vastly involved in the metabolism of various substances. This genPalabras claves:CYP2D6, CYP450, Metabolic profile, pharmacogenetics, Pharmacogenomics, polymorphism, Portuguese populationAutores:Adrián LLerena, Albuquerque J., Grazina M., Naranjo M.E.G., Ribeiro C.Fuentes:scopusClinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update
ReviewAbstract: Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokiPalabras claves:Autores:Adrián LLerena, Callaghan J.T., Caudle K.E., Fohner A.E., Formea C.M., Gaedigk A., Huddart R., Karnes J.H., Klein T.E., Mintzer S., Phillips E.J., Rettie A.E., Somogyi A.A., Ta Michael Lee M., Whirl-Carrillo M.Fuentes:scopusClinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors
ArticleAbstract: Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major depressive aPalabras claves:Autores:Adrián LLerena, Bishop J.R., Caudle K.E., Chiulli D.L., Gaedigk A., Graham R.L., Hicks J.K., Ji Y., Klein T.E., Leckband S.G., Leeder J.S., Muller D.J., Sangkuhl K., Scott S.A., Skaar T.C., Stingl J.C.Fuentes:scopusClinical drug-drug interactions: Focus on venlafaxine
ReviewAbstract: Venlafaxine (VEN) is an antidepressant agent widely used nowadays as an alternative to selective serPalabras claves:Drug-drug interactions, pharmacodynamics, pharmacokinetics, VenlafaxineAutores:Adrián LLerena, Alves G., Falcao A.C., Magalhães P.Fuentes:scopusClinical implementation of pharmacogenetics and personalized drug prescription based on e-health: The MedeA initiative
ArticleAbstract:Palabras claves:Autores:Adrián LLerena, Cobaleda J., de Andrés F., Mata-Martín C., Penãs-Lledó E.M., Pijierro A., Sánchez C.L.Fuentes:scopus