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A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes
ArticleAbstract: Cardiac electrophysiological computational models are often developed from previously published modePalabras claves:Autores:Carro J., Esther Pueyo, Rodriguez-Matas J.F.Fuentes:scopusConditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis
ArticleAbstract: Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explPalabras claves:Autores:Abarca-Lachen E., Brown B.M., Delgado-Wicke P., Esther Pueyo, Garcia-Otin A.L., Gilaberte Y., Giraldo P., Hamilton K.L., Juarranz Á., Köhler R., Lozano-Gerona J., Marigil M.Á., Miura H., Oliván-Viguera A., Osada J., Raychaudhuri S.P., Singh V., Surra J.C., Tapia-Casellas E., Valero M.S., Wulff H.Fuentes:scopusCorrection: Electrocardiographic biomarkers for detection of drug-induced late sodium current block (PLoS ONE (2016) 11:12 (e0163619) DOI: 10.1371/journal.pone.0163619)
OtherAbstract: The funding information is incomplete. The complete funding information is as follows: This projectPalabras claves:Autores:Esther Pueyo, Hosseini M., Johannesen L., Mason J.W., Sager P.T., Strauss D.G., Vicente J.Fuentes:scopusCorrection: Experimentally-based computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition (PLoS ONE (2016) 11:3 (e0151461) DOI: 10.1371/journal.pone.0151461)
OtherAbstract: The following information is missing from the Funding section: E.P. acknowledges the financial suppoPalabras claves:Autores:Britton O.J., Burrage K., Dangerfield C.E., Esther Pueyo, Jost N., Kistamás K., Nánási P.P., Rodríguez B., Szentandrássy N., Varro A., Virag L.Fuentes:scopusElectrocardiographic biomarkers for detection of drug-induced late sodium current block
ArticleAbstract: Background Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (EPalabras claves:Autores:Esther Pueyo, Hosseini M., Johannesen L., Mason J.W., Sager P.T., Strauss D.G., Vicente J.Fuentes:scopusInter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation
ArticleAbstract: Aims: Human atrial electrophysiology exhibits high inter-subject variability in both sinus rhythm (SPalabras claves:Autores:Bueno-Orovio A., Esther Pueyo, Loose S., Ravens U., Rodríguez B., Sanchez C., Simon J., Wettwer E.Fuentes:scopusPharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes
ArticleAbstract: Background TRPV4 channels are calcium-permeable cation channels that are activated by several physicPalabras claves:Autores:Abarca-Lachen E., Esther Pueyo, Garcia-Malinis A.J., Garcia-Otin A.L., Gilaberte Y., Hamilton K.L., Köhler R., Lozano-Gerona J., Oliván-Viguera A.Fuentes:scopusSudden cardiac death and pump failure death pbkp_rediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model
ArticleAbstract: Background: Sudden cardiac death (SCD) and pump failure death (PFD) are common endpoints in chronicPalabras claves:Autores:Cygankiewicz I., de Luna A.B., Esther Pueyo, Martínez J.P., Minchole A., Monasterio V., Orini M., Pablo Laguna, Ramirez J.Fuentes:scopusThe role of β-adrenergic stimulation in QT interval adaptation to heart rate during stress test
ArticleAbstract: The adaptation lag of the QT interval after heart rate (HR) has been proposed as an arrhythmic riskPalabras claves:Autores:Cebollada R., Esther Pueyo, Laguna P., Martínez J.P., Mountris K.A., Perez C.Fuentes:scopus