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Characterization of antimicrobial, antioxidant, and leishmanicidal activities of Schiff base derivatives of 4-aminoantipyrine
ArticleAbstract: Our main interest is the characterization of compounds to support the development of alternatives toPalabras claves:antimicrobial activity, Cytotoxicity, LEISHMANIA, Schiff base synthesisAutores:Ana Maria Poveda, Araya-Maturana R., Beske T., Jessica Mora, Jorge Hebkp_redia-Moya, Jorge Pérez-Barrera, Lizeth Dobronski, Olalla Barreiro-Costa, Patricio Rojas-Silva, Rommel Guevara, rommy TeranFuentes:scopusDiaza-1,3-butadienes as Useful Intermediate in Heterocycles Synthesis
ReviewAbstract: Many heterocyclic compounds can be synthetized using diaza-1,3-butadienes (DADs) as key structural pPalabras claves:diaza-1,3-butadienes, heterocycles, SynthesisAutores:Christian David Alcívar León, Daniel A. Zurita, Jorge Hebkp_redia-Moya, José Eduardo Cadena-CruzFuentes:googlescopusContamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde
ArticleAbstract: BACKGROUND: L-Threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa) is a norepinephrine (NE) prodrug uPalabras claves:Autores:Goldstein D.S., Holmes C., Jorge Hebkp_redia-Moya, Whittaker N.Fuentes:googlescopusEvaluation of Biological Activity of Natural Compounds: Current Trends and Methods
ReviewAbstract: Natural compounds have diverse structures and are present in different forms of life. Metabolites suPalabras claves:Antimicrobial, antioxidant, bioactive compounds, Natural productAutores:Arianna Mayorga-Ramos, Benjamín Arias-Almeida, Carlos Barba-Ostria, Cristina Rodríguez-Pólit, Johana Zúñiga-Miranda, Jorge Hebkp_redia-Moya, Linda P. Guamán, REBECA GONZALEZ-PASTOR, Saskya E. Carrera-PachecoFuentes:scopusEvaluation of the Anti-Leishmania mexicana and -Trypanosoma brucei Activity and Mode of Action of 4,4′-(Arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)
ArticleAbstract: Trypanosomiasis and leishmaniasis are neglected infections caused by trypanosomatid parasites. The fPalabras claves:4,4′-(arylmethylene)bis(1H-pyrazol-5-ols), Adme, drug-like, LEISHMANIA, redox biosensor, TrypanosomaAutores:Comini M.A., Erika B. Muñoz, Jorge Hebkp_redia-Moya, Medeiros A., Olalla Barreiro-Costa, Patricio Rojas-Silva, Quiroga Lozano C.Fuentes:scopusEffects of simple and angular chromones on tumor cell respiration
ArticleAbstract: A set of structurally related compounds incorporating a chromone moiety as an essential component ofPalabras claves:Cáncer, Cell respiration, ChromoneAutores:Araya-Maturana R., Donoso-Tauda O., Ferreira J., Hernández J.T., Jorge Hebkp_redia-Moya, Pavani M., Pessoa-Mahana H., Vera M., Weiss-López B.Fuentes:googlescopusOxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome
ArticleAbstract: The most common cause of cardiac side effects of pharmaco-therapy is acquired long QT syndrome, whicPalabras claves:Autores:Dennis A.T., Ficker E., Jorge Hebkp_redia-Moya, Kirk K.L., Obejero-Paz C., Overholt J.L., Wan X.Fuentes:googlescopusSynthesis and evaluation of biological activities of bis(Spiropyrazolone)cyclopropanes: A potential application against Leishmaniasis
ArticleAbstract: This work focuses on the search and development of drugs that may become new alternatives to the comPalabras claves:Adme, Bis(spiropyrazolone)cyclopropanes, drugs, Leishmaniasis cytotoxicityAutores:Ana Herrera, Ana Maria Poveda, Cristina Cueva, Eliana Lara-Barba, Gabriela Morales-Noboa, Javier Santamaría-Aguirre, Jorge Hebkp_redia-Moya, Juan Carlos Romero-Benavides, Natalia Bailon-Moscoso, Olalla Barreiro-Costa, Patricio Rojas-Silva, Ron-Garrido L.Fuentes:scopusSynthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities
ArticleAbstract: Background: Pyrazoles have attracted particular attention due to the diverse biological activities aPalabras claves:4,4ʹ-(arylmethylene)bis(1H-pyrazol-5-ols), antioxidant, apoptosis, AutophagyAutores:Jorge Hebkp_redia-Moya, José Eduardo Cadena-Cruz, Juan Carlos Romero-Benavides, Kevin E. Murillo-Sotomayor, Luis Guaman, Luis Miguel Guamán Ortíz, Nadia V. Ortiz-Guamán, Natalia Bailon-MoscosoFuentes:googlescopusSynthesis, experimental and theoretical study of novel 2-haloalkyl (-CF<inf>2</inf>H, -CCl<inf>2</inf>H, -CF<inf>2</inf>CF<inf>3</inf>)-, 3-bromo and bromomethyl substituted chromones
ArticleAbstract: A set of seven new chromones with 2-haloalkyl (-CF2H, -CCl2H, -CF2CF3) and 3-bromo and bromomethyl sPalabras claves:2-haloalkyl chromones, Halogen bonds, Hirshfeld surface analysis, Quantum chemical calculations, Spectroscopic properties, structural X-ray diffractionAutores:Christian D. Alcívar L, Echeverría G.A., Ena G. Narváez O, Jios J.L., Jorge Hebkp_redia-Moya, Langer P., Pablo M. Bonilla V, Piro O.E., Ulic S.E., Zurita-Saltos D.A.Fuentes:scopus