Mostrando 10 resultados de: 25
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Bioorganic and Medicinal Chemistry(2)
Bioorganic and Medicinal Chemistry Letters(2)
Journal of Agricultural and Food Chemistry(2)
Journal of Liquid Chromatography and Related Technologies(2)
Biochemical Pharmacology(1)
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Farmacología y terapéutica(14)
Química orgánica(8)
Fisiología humana(4)
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Enfermedades(3)
Analysis of vervain flavonoids by HPLC/diode array detector method. Its application to quality control
ArticleAbstract: A reversed-phase HPLC procedure is proposed for the determination of seven flavonoids (luteolin, nepPalabras claves:Chemical fingerprint, flavonoids, HPLC/DAD detector, Quality control, Vervain (Lippia citriodora)Autores:Andrade P.B., Ferreres F., Filipe Miguel Areias, Seabra R.M., Valentao P.Fuentes:googlescopusAntifungal activity of a novel chromene dimer
ArticleAbstract: The activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimersPalabras claves:Antifungal compounds, Aspergillus spp., Chromenes, Ochratoxin AAutores:Abrunhosa L., Costa M., Filipe Miguel Areias, Proença M.F., Venâncio A.Fuentes:googlescopusAntioxidant effect of flavonoids after ascorbate/Fe<sup>2+</sup>-induced oxidative stress in cultured retinal cells
ArticleAbstract: In this study, we investigated the structure-activity relationship of four flavonoids, i.e. eriodictPalabras claves:Antioxidants, flavonoids, Oxidative Stress, Retinal cellsAutores:Filipe Miguel Areias, Oliveira C.R., Rego A.C., Seabra R.M.Fuentes:googlescopus2-Aryladenine derivatives as a potent scaffold for A<inf>1</inf>, A<inf>3</inf> and dual A<inf>1</inf>/A<inf>3</inf> adenosine receptor antagonists: Synthesis and structure-activity relationships
ArticleAbstract: From a collection containing more than 1500 academic compounds, in silico screening identified a hitPalabras claves:2-Arylpurine derivatives, Adenine derivatives, Adenosine receptor antagonistsAutores:Brea J., Carvalho M.A., Castro M., Correia C., Filipe Miguel Areias, Loza M.I., Proença M.F., Rocha A.Fuentes:googlescopusA base-catalyzed cascade route to phenolic 6-cyanopurines via O -alkylformamidoximes
ArticleAbstract: N-[1,2-Dicyano-2-(hydroxyphenylideneamino)vinyl]-O-alkylformamidoximes were prepared from the reactiPalabras claves:amidoximes, Imidazoles, nitrogen heterocycles, phenols, purinesAutores:Filipe Miguel Areias, Proença M.F.Fuentes:googlescopusGlutamate regulates the viability of retinal cells in culture
ArticleAbstract: In this study, we show that glutamate regulates the viability of cultured retinal cells upon transiePalabras claves:Excitotoxicity, glutamate, Mitochondria, NMDA receptors, Retinal cellsAutores:Filipe Miguel Areias, Oliveira C.R., Proença T., Rego A.C., Santos M.S.Fuentes:googlescopusFlavonoids and phenolic acids of sage: Influence of some agricultural-factors
ArticleAbstract: A reversed-phase high-performance liquid chromatography/diode-array detector procedure is proposed fPalabras claves:HPLC/DAD, Phenolic profile, Quality control, Sage (Salvia officinalis)Autores:Andrade P.B., Ferreres F., Filipe Miguel Areias, Seabra R.M., Valentao P.Fuentes:googlescopusEffect of glucose deprivation and acute glutamate exposure in cultured retinal cells
ArticleAbstract: The relationship between bioenergetics and the glutamate system was analyzed in a neuronal model ofPalabras claves:Ca uptake 2+, Cell injury, Energy charge, Glucose deprivation, glutamate, Membrane potential, Retinal cellsAutores:Filipe Miguel Areias, Oliveira C.R., Rego A.C., Santos M.S.Fuentes:googlescopusDistinct glycolysis inhibitors determine retinal cell sensitivity to glutamate-mediated injury
ArticleAbstract: In this study, we analyzed how distinct glycolysis inhibitors influenced the redox status of retinalPalabras claves:ATP production, glutamate, Glycolysis, MTT reduction, Retinal cell injuryAutores:Filipe Miguel Areias, Oliveira C.R., Rego A.C., Santos M.S.Fuentes:googlescopusNew chromene scaffolds for adenosine A<inf>2A</inf> receptors: Synthesis, pharmacology and structure-activity relationships
ArticleAbstract: In silico screening of a collection of 1584 academic compounds identified a small molecule hit for tPalabras claves:Adenosine receptors, Chromene scaffolds, G protein-coupled receptors, Knoevenagel condensation, Structure-activity relationshipAutores:Brea J., Castro M., Costa M., Filipe Miguel Areias, Gregori-Puigjané E., Loza M.I., Mestres J., Proença M.F.Fuentes:googlescopus