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Chemical Conjugation in Drug Delivery Systems
ReviewAbstract: Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usuPalabras claves:Biomolecules, Carriers, covalent bioconjugation, Drug delivery systems, linkersAutores:Alberício F., Alexis Eras, Danna Castillo, Hortensia Rodriguez Cabrera, Santiago Nelson Vispo, Suárez Navarro M.Fuentes:scopusAlkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents
ArticleAbstract: The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2- thione (bis-THTT) on LeiPalabras claves:Alkyl-linked bis-THTT anti-protozoal activityAutores:Alvarez A., Atherton R., Coro J., Hortensia Rodriguez Cabrera, Little S., Perez-Pineiro R., Suárez Navarro M., Wharton H., Yardley V.Fuentes:googlescopusAn Androsterone-H<inf>2</inf>@C<inf>60</inf> hybrid: Synthesis, Properties and Molecular Docking Simulations with SARS-Cov-2
ArticleAbstract: We report the synthesis and characterization of a fullerene-steroid hybrid that contains H2@C60 andPalabras claves:cyclopropanation, Fullerenes, Molecular docking, SARS-COV-2, Steroid hybridsAutores:Alberício F., Almagro L., Herranz M.Á., Hortensia Rodriguez Cabrera, Lemos R., Makowski K., Maroto E., Martín N., Molero D., Murata Y., Ortiz O., Suárez Navarro M.Fuentes:scopusIn vitro and in vivo assays of 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives against Trypanosoma cruzi
ArticleAbstract: Cytotoxicity assays of 24 new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivativesPalabras claves:AMASTIGOTES, Antichagasic drugs, Antitrypanosomal activity assays, Cytotoxicity assays, J774 macrophages, Thiadiazine thione derivativesAutores:García-Trevijano J.A.E., Gómez-Barrio A., Hortensia Rodriguez Cabrera, Muelas S., Ochoa C., Perez-Pineiro R., Suárez Navarro M.Fuentes:googlescopusSynthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids
ArticleAbstract: Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3- yl) carboxylic acids werePalabras claves:Antiparasitics, chemotherapy, Thiadiazine-2-thioneAutores:Coro J., Gómez-Barrio A., Hortensia Rodriguez Cabrera, Montero D., Nogal-Ruiz J.J., Perez-Pineiro R., Rolón M.S., Suárez Navarro M., Vega C.Fuentes:scopusSynthesis and antiprotozoan properties of new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives
ArticleAbstract: In a search for antiprotozoan compounds, 34 new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2Palabras claves:2H-1,3,5-Thiadiazine-2-thione derivatives, Antiprotozoans, In vitro and in vivo studies, Synthesis, Trichomonas vaginalis, TRYPANOSOMA CRUZIAutores:Gómez-Barrio A., Hortensia Rodriguez Cabrera, Martínez R.A., Muclas S., Nogal-Ruiz J.J., Ochoa C., Ochoa E., Perez E., Pérez R., Suárez Navarro M.Fuentes:googlescopusSynthesis of [60]Fullerene Hybrids Endowed with Steroids and Monosaccharides: Theoretical Underpinning as Promising anti-SARS-CoV-2 Agents
ArticleAbstract: Cyclopropanation reactions between C60 and different malonates decorated with monosaccharides and stPalabras claves:Molecular docking, SARS-COV-2, sugar steroid hybrids, Theoretical calculations, [60]FullereneAutores:Almagro L., Herranz M.Á., Hortensia Rodriguez Cabrera, Lemos R., Makowski K., Martín N., Molero D., Suárez Navarro M., Tolón B.Fuentes:scopusQuantitative structured antitumoral-activity relationships of thiadiazinthione derivatives using the novel hybrid molecular index <sup>p</sup>MR<inf>χ</inf>
ArticleAbstract: Purpose. The recently defined molarrefractivity-partition index was applied to a family of 1,3,5- thPalabras claves:Autores:Carrasco R., Hortensia Rodriguez Cabrera, Ochoa C., Padrón J.A., Perez-Pineiro R., Suárez Navarro M.Fuentes:googlescopus