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A strong protective action of Guttiferone-A, a naturally occurring prenylated benzophenone, against iron-induced neuronal cell damage
ArticleAbstract: Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmPalabras claves:antioxidant, Guttiferone-A, Iron, Iron chelation, neuroprotectionAutores:Curti C., García-Pupo L., Naal Z., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., René D.H.Fuentes:googlescopusEffect of a new series of synthetic spiroteroids on the PC12 cell line viability
ArticleAbstract: Introduction: diosgenin and its derivatives have been described as potent anti-proliferative compounPalabras claves:Cytotoxicity, Spirosteroids, Structure-activity relationship, Taurodeoxycholic acidAutores:García-Pupo L., Juan Enrique Tacoronte-Morales, Núñez-Figueredo Y., René D.H.Fuentes:scopusDiscerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities
ArticleAbstract: Oxidative stress resulting from iron and reactive oxygen species (ROS) homeostasis breakdown has beePalabras claves:antioxidant, Iron, Iron-chelation, Mitochondria, Quinones, RapanoneAutores:Antuch M., de la Vega-Hernández K., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L.Fuentes:googlescopusNeuroprotective action and free radical scavenging activity of guttiferone-A, a naturally occurring prenylated benzophenone
ArticleAbstract: Reactive oxygen species (ROS) are important mediators in a number of neurodegenerative diseases andPalabras claves:glutamate, Guttiferone-A, Hydrogen Peroxide, neuroprotective drug, PC12 cells, rat cortical neuronsAutores:Alcántara-Isaac Y., Curti C., García-Pupo L., Hernández R.D., Naal Z., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Ramírez-Sánchez J.Fuentes:googlescopusObtention of dry extract from aqueous extracts of Justicia pectoralis Jacq. (tilo)
ArticleAbstract: Introduction: Justicia pectoralis Jacq. (Acanthaceae), is a medicinal species native to the AmericanPalabras claves:Aqueous extract, coumarin, Justicia pectoralis Jacq., Pharmacological evaluation, Response Surface Methodology, sedative activity, spray dryingAutores:Nogueira-Mendoza A., Núñez-Figueredo Y., Orestes Darío López-Hernández, Rodríguez Ferrada C., Rodríguez-Chanfrau J.E.Fuentes:googlescopusIn vitro neuroprotective and anti-inflammatory activities of natural and semi-synthetic spirosteroid analogues
ArticleAbstract: Two spirosteroid analogues were synthesized and evaluated for their in vitro neuroprotective activitPalabras claves:Excitotoxicity, inflammatory mediators, neuroprotection, SpirosteroidsAutores:Exarchou V., García-Pupo L., Juan Enrique Tacoronte-Morales, Núñez-Figueredo Y., Pieters L., René D.H., Vanden Berghe W., Zaldo-Castro A.Fuentes:scopusThe anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: Ensuing energetic and oxidative stress implications
ArticleAbstract: Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with cytotoxic action in viPalabras claves:Anti-cancer action, Guttiferone-A, HepG2 cells, Mitochondria, Mitochondrial membrane permeabilization, Oxidative Stress, UncouplingAutores:Alberici L.C., Curti C., Leopoldino A.M., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Pestana C.R., Rodrigues F.P., Tudella V.G., Uyemura S.A.Fuentes:googlescopusThe anti-cancer agent nemorosone is a new potent protonophoric mitochondrial uncoupler
ArticleAbstract: Nemorosone, a natural-occurring polycyclic polyprenylated acylphloroglucinol, has received increasinPalabras claves:Cáncer, HepG2 cell death, Mitochondria, nemorosone, Protonophore, UncouplerAutores:Alberici L.C., Curti C., Leopoldino A.M., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Pestana C.R., Rodrigues F.P., Tudella V.G., Uyemura S.A.Fuentes:googlescopusThe cytotoxic effects of brown Cuban propolis depend on the nemorosone content and may be mediated by mitochondrial uncoupling
ArticleAbstract: Three main types of Cuban propolis directly related to their secondary metabolite composition have bPalabras claves:Cuban propolis, Cytotoxic, Mitochondria, nemorosone, Toxicity, UncouplingAutores:Alberici L.C., Curti C., Dalalio F.M., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Reis F.H.Z., Uyemura S.A.Fuentes:googlescopus