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Carbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicity
ArticleAbstract: Methylglyoxal (MG) is a reactive α-ketoaldehyde physiologically generated as a by-product of glycolyPalabras claves:Carbonyl stress, Free radicals, methylglyoxal, Mitochondria, Neurodegeneration, NMDA receptorsAutores:Allgaier C., Antoni Camins, Garcia De Arriba S., García-Jordà E., Krügel U., Lewerenz A., Münch G., Nieber K., Pallás M., Regenthal R., Verdaguer E., Vissiennon Z.Fuentes:scopusDifferent capacities of various NMDA receptor antagonists to prevent ischemia-induced neurodegeneration in human cultured NT2 neurons
ArticleAbstract: In the present study, human NT2 neurons obtained from embryonic teratocarcinoma (NT2) cells were estPalabras claves:Cultured human NT2 neurons, Glycine binding site antagonists B, immunocytochemistry, ischemia, NMDA receptors, Patch-clamp recordingsAutores:Allgaier C., Antoni Camins, Garcia De Arriba S., Grüner K., Pallás M., Verdaguer E., Wagner A., Wegner F., Wohlfahrt K.Fuentes:scopus