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A criterion for the selection of monophasic solvents for enzymatic synthesis
ArticleAbstract: Penicillin acylase can be used for the production of β-lactamic antibiotics which have a wide rangePalabras claves:Antibiotic, Enzyme stability, Equilibrium-controlled synthesis, Organic solvent selection, Penicillin acylaseAutores:Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M., Terreni M.Fuentes:scopusAdditional stabilization of penicillin G acylase-agarose derivatives by controlled chemical modification with formaldehyde
ArticleAbstract: We have tested the effect of chemical modifications with formaldehyde on the activity/stability of iPalabras claves:chemical modification of proteins, Enzyme stabilization, formaldehyde treatment of enzymes, immobilization-stabilization of enzymesAutores:Alvaro G., Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M.Fuentes:scopusFacile synthesis of artificial enzyme nano-environments via solid-phase chemistry of immobilized derivatives: Dramatic stabilization of penicillin acylase versus organic solvents
ArticleAbstract: A method to generate a highly hydrophilic nano-environment surrounding immobilized enzymes [penicillPalabras claves:Artificial nano-environments, Dextrans, Enzymes in organic media, Immobilized enzymes, Solid-phase modification of proteins, Stabilization of enzymesAutores:Caanan-Haden L., Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M., Rodes L.Fuentes:scopusEnzyme reaction engineering: Synthesis of antibiotics catalysed by stabilized penicillin G acylase in the presence of organic cosolvents
ArticleAbstract: By using very active and very stable penicillin G acylase (PGA)-agarose derivatives we have studiedPalabras claves:antibiotic synthesis by penicillin G acylase, design of thermodynamically controlled synthesis, enzymes in organic solvents, Enzymes in organic synthesisAutores:Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M.Fuentes:scopusModulation of the properties of penicillin G acylase by acyl donor substrates during N-protection of amino compounds
ArticleAbstract: The rates and yields in the synthesis of N-protected amino compounds catalyzed by penicillin G acylaPalabras claves:Enzyme modulation, Enzymes (in fine chemistry), Optically pure compound synthesis, Penicillin G acylase, Protection of amino compoundsAutores:Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M.Fuentes:scopusPreparation of activated supports containing low pK amino groups. A new tool for protein immobilization via the carboxyl coupling method
ArticleAbstract: A method for the preparation of new aminated agarose gels containing monoaminoethyl-N-aminoethyl strPalabras claves:Agarose gel, carboxyl coupling, monoaminoethyl-N-aminoethyl structures, protein immobilization, β-galactosidaseAutores:Bastida A., Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M., Rodríguez V., Santana C., Soler G.Fuentes:scopusStrategies for enzyme stabilization by intramolecular crosslinking with bifunctional reagents
ArticleAbstract: A original strategy to obtain intramolecular crosslinking is discussed. This strategy consisted of tPalabras claves:chemical modification of proteins, Formaldehyde, GLUTARALDEHYDE, Penicillin G acylase, Protein crosslinking, Stabilization of enzymesAutores:Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M., Rodríguez V.Fuentes:scopusSynthesis of antibiotics (cephaloglycin) catalyzed by penicillin G acylase: Evaluation and optimization of different synthetic approaches
ArticleAbstract: Two different approaches have been utilized to synthesize cephaloglycin using immobilized-stabilizedPalabras claves:Antibiotics, Cephaloglycin, Penicillin G acylase, SynthesisAutores:Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M., Piatkowska B.Fuentes:scopusThe presence of methanol exerts a strong and complex modulation of the synthesis of different antibiotics by immobilized Penicillin G acylase
ArticleAbstract: The yields in the synthesis of antibiotics catalyzed by Penicillin G acylase under very mild experimPalabras claves:Modulation of enzymes, Penicillin G acylase, Synthesis of antibioticsAutores:Cristina M. Rosell, Fernandez‐Lafuente R., Guisan J.M.Fuentes:scopus