Mostrando 10 resultados de: 27
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Bioorganic and Medicinal Chemistry Letters(3)
Journal of Medicinal Chemistry(3)
Journal of Peptide Science(3)
Amino Acids(2)
Bioconjugate Chemistry(2)
Área temáticas
Farmacología y terapéutica(14)
Bioquímica(13)
Química orgánica(8)
Microorganismos, hongos y algas(6)
Enfermedades(3)
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scopus(27)
An optimized Fmoc synthesis of human defensin 5
Conference ObjectAbstract: Human α-defensin 5 (DEF5), expressed by the Paneth cells of human small intestine, plays an importanPalabras claves:ChemMatrix resin, Fmoc solid-phase peptide synthesis, Human defensin 5, Pseudoproline dipeptidesAutores:Andreu D., B. G. De la Torre, Valle J., Vernieri E.Fuentes:scopusA BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drug
ArticleAbstract: Therapeutic application of many drugs is often hampered by poor or denied access to intracellular taPalabras claves:BODIPY, cell-penetrating peptide, Dual fluorescent labeling, Miltefosine, Monitoring of intracellular drug delivery, Reversion of resistanceAutores:Abengózar M.Á., Amat-Guerri F., Andreu D., B. G. De la Torre, Hornillos V., Luque-Ortega J.R., Rivas L., Ulises Acuña A.Fuentes:scopusA novel cell-penetrating peptide sequence derived by structural minimization of a snake toxin exhibits preferential nucleolar localization
ArticleAbstract: Structural simplification of a 42-residue venom peptide by N-to-C-terminal splicing led to two sequePalabras claves:Autores:Andreu D., B. G. De la Torre, Rádis-Baptista G.Fuentes:scopusConformational analysis of peptides and glycopeptides derived from the consensus sequence for β-O-glucosylation
ArticleAbstract: Cys-Xxx-Ser-Xxx-Pro-Cys (Xxx= any amino acid but Pro) is the most common sequence present in naturalPalabras claves:Conformational analysis, molecular dynamics, Nuclear magnetic resonance, β-O-glucosylationAutores:Andreu D., Asensio J.L., Avenoza A., B. G. De la Torre, Busto J.H., Corzana F., Fernández-Tejada A., Jiménez-Barbero J., Martínez-Sáez N., Peregrina J.M., Somovilla V.J.Fuentes:scopusCyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor
ArticleAbstract: Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas wPalabras claves:BDNF, Growth factors, Peptides, Secondary peptide structure mimetics, β-TurnAutores:Almeida R.D., Andreu D., B. G. De la Torre, Baeza J.L., Garcı́a-López M.T., Gerona-Navarro G., Gonzalez-Muniz R., Jaffrey S.R., Jiménez M.A., Martín-Martínez M., Santiveri C.M.Fuentes:scopusEssential Role of Enzymatic Activity in the Leishmanicidal Mechanism of the Eosinophil Cationic Protein (RNase 3)
ArticleAbstract: The recruitment of eosinophils into Leishmania lesions is frequently associated with a favorable evoPalabras claves:Antimicrobial peptide, cell-penetrating enzyme, membrane disruption, protozoa, RNaseAutores:Abengózar M.Á., Andreu D., B. G. De la Torre, Boix E., Fernández-Reyes M., Rivas L., Salazar V.A., Torrent M.Fuentes:scopusEfficient cellular delivery of β-galactosidase mediated by NrTPs, a new family of cell-penetrating peptides
ArticleAbstract: Nucleolar targeting peptides (NrTPs), a recently developed family of cell-penetrating peptides, havePalabras claves:Autores:Andreu D., B. G. De la Torre, Rádis-Baptista G., Rodrigues M., Santos N.C.Fuentes:scopusNMR structural determinants of eosinophil cationic protein binding to membrane and heparin mimetics
ArticleAbstract: Eosinophil cationic protein (ECP) is a highly stable, cytotoxic ribonuclease with the ability to entPalabras claves:Autores:Andreu D., B. G. De la Torre, Boix E., Bruix M., García-Mayoral M.F., Laurents D., Moussaoui M., Nogués V., Rico M.Fuentes:scopusNeo-glycopeptides: The importance of sugar core conformation in oxime-linked glycoprobes for interaction studies
ArticleAbstract: Carbohydrate binding proteins, such as lectins, are crucial in numerous biological recognition procePalabras claves:Carbohydrate-lectin interaction, Oxime-linked glycopeptides, Secondary amine, SPRAutores:Andreu D., B. G. De la Torre, Gutiérrez-Gallego R., Jiménez-Castells C.Fuentes:scopusNucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: Design and mechanism of action
ArticleAbstract: Cell penetrating peptides (CPPs) can be used as drug delivery systems for different therapeutic molePalabras claves:capsid protein, cell penetrating peptide, Dengue Virus, Gene therapy, time-resolved flow cytometryAutores:Andreu D., B. G. De la Torre, Castanho M.A.R.B., Da Poian A.T., Freire J.M., Rego De Figueiredo I., Santos N.C., Veiga A.S.a.Fuentes:scopus