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Organic Letters(2)
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A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks
ArticleAbstract: (Chemical Equation Presented) The technique of choice for synthesis of small-scale depsipeptides isPalabras claves:Autores:Alberício F., Burger K., Jan Spengler, Ruíz-Rodríguez J.Fuentes:googlescopusA novel protecting/activating strategy for β-hydroxy acids and its use in convergent peptide synthesis
ArticleAbstract: (Chemical Equation Presented) β-Hydroxy acids were reacted with hexafluoroacetone and carbodiimidesPalabras claves:Autores:Alberício F., Burger K., Jan Spengler, Royo M., Ruíz-Rodríguez J., Winter M., Yraola F.Fuentes:googlescopusApplication of hexafluoroacetone as protecting and activating reagent in solid phase peptide and depsipeptide synthesis
ArticleAbstract: Hexafluoroacetone-protected/activated hydroxy acids [2,2- bis(trifluoromethyl)-1,3-dioxolan-4-ones]Palabras claves:Bidentate reagents, Citramalic acid, Hexafluoroacetone, Tetrahydroisoquinoline carboxylic acidAutores:Alberício F., Burger K., Cupido T., Jan Spengler, Ruiz J.Fuentes:googlescopusAbbreviated nomenclature for cyclic and branched homo- and hetero-detic peptides
ArticleAbstract: Amino acid sequences and linear or head-to-tail cyclopeptides can be represented conveniently in onePalabras claves:Abbreviated nomenclature, Branched peptides, Connected peptide strands, Cyclopeptides, One-line text formulae, RecommendationAutores:Alberício F., Burger K., Giralt E., Jan Spengler, Jiménez J.Fuentes:scopusOrthogonally protected, carboxy-activated L-homoisoserine, 2-methyl-L-homoisoserine, and homoisocysteine derivatives. New building blocks for peptide and depsipeptide modification
ArticleAbstract: Starting from L-malic, L-citramalic, and rac. thiomalic acids routes to L-homoisoserine, 2-methyl-L-Palabras claves:Arndt-Eistert reaction, Azapeptides, Citramalic acid, Curtius rearrangement, Depsipeptide modification, Hexafluoroacetone, malic acid, Peptide modification, Thiomalic acid, Wolff rearrangement, α-Hydroxy acids, α-Mercapto acids, γ-Amino acidsAutores:Alberício F., Böttcher C., Burger K., Hennig L., Jan Spengler, Radics G.Fuentes:googlescopusIncorporation of the α-mercapto acid unit into peptides
ArticleAbstract: Incorporation of α-mercapto acid units into the backbone of potential drug candidates improves the mPalabras claves:Acylations, Dielectrophiles, Hexafluoroacetone, Peptides, Thiols, Thiomalic acidAutores:Alberício F., Burger K., Haas A., Jan Spengler, Pumpor K.Fuentes:googlescopusL-α-Methylhomoisoserine: A New Versatile Building Block for Peptide and Depsipeptide Modification
ArticleAbstract: An efficient access to L-α-methylhomoisoserine derivatives starting from L-citramalic acid is descriPalabras claves:Amino acid hydroxamates, Arndt-Eistert synthesis, Citramalic acid, Curtius rearrangement, Hexafluoroacetone, Wolff rearrangement, γ-amino-α-hydroxy-α -methylbutyric acidAutores:Burger K., El-Kousy S.M., Jan Spengler, Koksch B., Radics G.Fuentes:googlescopusp-Nitromandelic acid as a highly acid-stable safety-catch linker for solid-phase synthesis of peptide and depsipeptide acids
ArticleAbstract: Equation presented p-Nitromandelic acid as a safety-catch linker for Boc/Bzl-SPPS of base-labile comPalabras claves:Autores:Alberício F., Alvarez M., Burger K., Isidro-Llobet A., Jan SpenglerFuentes:googlescopus