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2,5-Diketopiperidine derivatives as non-peptide ligands for cholecystokinin receptors
ArticleAbstract: Easily accessible 2,5-diketopiperidines have been used as templates for the construction of Trp-PhePalabras claves:Autores:Del Río J., Dominguez M.J., Fortuno A., Garcı́a-López M.T., Gonzalez-Muniz R., Herranz R., Santiago J. BallazFuentes:googlescopus2-Oxopyrrolidines and 6-oxoperhydropyrrolo[1,2-a]pyrazines as templates in the search for nonpeptide cholecystokinin ligands
ArticleAbstract: In order to find new classes of non-peptide cholecystokinin (CCK) ligands, the conformational restriPalabras claves:2-Oxopyrrolidine, Cholecystokinin mimetic, Perhydropyrrolo[1,2-a]pyrazineAutores:Cenarruzabeitia E., Del Río J., Garcı́a-López M.T., Gonzalez-Muniz R., Herranz R., LaTorre M., Martín-Martínez M., Santiago J. BallazFuentes:googlescopus5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK<inf>1</inf> receptor antagonists: Structural modifications at the tryptophan domain
ArticleAbstract: Analogues of the previously reported potent and highly selective CCK1 receptor antagonist (4aS,5R)-2Palabras claves:Autores:Bartolomé-Nebreda J.M., Cenarruzabeitia E., Del Río J., Garcı́a-López M.T., Gómez-Monterrey I., Gonzalez-Muniz R., Herranz R., LaTorre M., Martín-Martínez M., Santiago J. BallazFuentes:scopusPharmacological evaluation of IQM-95,333, a highly selective CCK(A) receptor antagonist with anxiolytic-like activity in animal models
ArticleAbstract: 1. The pyridopyrimidine derivative IQM-95,333 ((4aS,5R)-2-benzyl-5-[N(α)-tert-butoxicarbonyl)L-tryptPalabras claves:Amylase release, Anxiolytic drugs, CCK(A) receptors, CCK(B) receptors, Cholecystokinin (CCK), Food intakeAutores:Barber A., Del Río J., Fortuno A., Garcı́a-López M.T., Gómez-Monterrey I., Gonzalez-Muniz R., Herranz R., Martín-Martínez M., Santiago J. BallazFuentes:scopusPseudopeptide CCK-4 analogues incorporating the Ψ[CH(CN)NH] peptide bond surrogate
ArticleAbstract: The synthesis, binding to CCK receptors, and in vitro functional activity of pseudopeptide CCK-4 anaPalabras claves:Autores:Barber A., Del Río J., Fortuno A., Garcı́a-López M.T., Gonzalez-Muniz R., Herranz R., Herrero S., Santiago J. Ballaz, Suárez-Gea M.L.Fuentes:scopusSynthesis and stereochemical structure activity relationships of 1,3- dioxoperhydropyrido[1,2-c]pyrimidine derivatives: Potent and selective cholecystokinin-a receptor antagonists
ArticleAbstract: The synthesis and stereochemical structure-activity relationships of a new class of potent and selecPalabras claves:Autores:Barber A., Bartolomé-Nebreda J.M., Del Río J., Fortuno A., Garcı́a-López M.T., Gómez-Monterrey I., Gonzalez-Muniz R., Herranz R., Martín-Martínez M., Santiago J. BallazFuentes:googlescopusSynthesis of chiral 1,6,8-trioxoperhydropyrazino[1,2-c]pyrimidines as novel highly functionalized scaffolds for peptidomimetics
ArticleAbstract: The synthesis of novel chiral 4,7-disubstituted- and 2,4,7-trisubstituted-1,6,8-trioxoperhydropyraziPalabras claves:1,6,8-trioxoperhydropyrazino[1,2-c]pyrimidines, 3,5-disubstituted-2-oxopiperazines, Lactams, Nitrogen bridged bicyclic heterocycles, Peptidomimetics, Urea derivatives, Ψ[CH(CN)NH] pseudodipeptidesAutores:Antonio Salgado, Garcı́a-López M.T., Herranz R., Herrero S.Fuentes:scopus