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CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
ArticleAbstract: CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognatePalabras claves:CD69, HIF-1α, Hypoxia, tumor microenvironment, tumor-infiltrating lymphocytes (TILs)Autores:Aragonés J., Aznar M.Á., Azpilikueta A., Bolaños E., de la Fuente H., Etxeberria I., Garasa S., Labiano S., Maiso P., Manuel Ortiz de Landázuri, Meléndez-Rodríguez F., Melero I., Molina C., Palazón A., Sánchez-Paulete A.R., Sánchez‐Madrid F., Teijeira A.Fuentes:scopusDithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage
ArticleAbstract: It has recently been shown that the alteration of the cell-redox status affects the transcription faPalabras claves:Autores:Aragonés J., Corbí A.L., Del Arco P.G., López-Cabrera M., López-Rodríguez C., Manuel Ortiz de Landázuri, Redondo J.M.Fuentes:scopusMyeloid hypoxia-lnducible factors in inflammatory diseases
ArticleAbstract: Hypoxia inducible factors (HIFI and HIF2) have emerged as central regulators of the activity of myelPalabras claves:Hypoxia, Hypoxia-inducible factor (HIF), inflammation, MacrophagesAutores:Acosta-Lborra B., Aragonés J., Elorza A., Manuel Ortiz de LandázuriFuentes:scopusMacrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-γ production through the HIF-1α transcription factor
ArticleAbstract: Low oxygen tension areas are found in inflamed or diseased tissues where hypoxic cells induce survivPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Calzada M.J., Elorza A., Manuel Ortiz de Landázuri, Martín-Cofreces N.B., Martin-Puig S., Miro M., Olazabal I.M., Sánchez‐Madrid F.Fuentes:scopusReduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions
ArticleAbstract: The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subseqPalabras claves:adhesion, antioxidant, flow, Hypoxia, NeutrophilAutores:Aragonés J., Del Pozo M.A., Luscinskas F.W., Manuel Ortiz de Landázuri, Montoya M.C.Fuentes:scopusPyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: Modulation of NF- κB and AP-1 transcription factors activity
ArticleAbstract: Endothelial cells (EC) play a key role in the inflammatory response, both by the production of proinPalabras claves:Autores:Alfranca A., Aragonés J., Castellanos M.D.C., Manuel Ortiz de Landázuri, Muñoz C., Pascual-Salcedo D., Redondo J.M., Vara A.Fuentes:scopusThe HIF-1α hypoxia response in tumor-infi ltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
ArticleAbstract: The tumor microenvironment of transplanted and spontaneous mouse tumors is profoundly deprived of oxPalabras claves:Autores:Alfaro C., Aragonés J., Hervás-Stubbs S., Jure-Kunkel M., Manuel Ortiz de Landázuri, Martínez-Forero I., Melero I., Morales-Kastresana A., Palazón A., Peñuelas I., Perez-Gracia J.L., Rouzaut A., Sanmamed M.F., Teijeira A.Fuentes:scopus