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CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
ArticleAbstract: CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognatePalabras claves:CD69, HIF-1α, Hypoxia, tumor microenvironment, tumor-infiltrating lymphocytes (TILs)Autores:Aragonés J., Aznar M.Á., Azpilikueta A., Bolaños E., de la Fuente H., Etxeberria I., Garasa S., Labiano S., Maiso P., Manuel Ortiz de Landázuri, Meléndez-Rodríguez F., Melero I., Molina C., Palazón A., Sánchez-Paulete A.R., Sánchez‐Madrid F., Teijeira A.Fuentes:scopusAcute Vhl gene inactivation induces cardiac HIF-Dependent erythropoietin gene expression
ArticleAbstract: Von Hippel Lindau (Vhl) gene inactivation results in embryonic lethality. The consequences of its inPalabras claves:Autores:Albacete-Albacete L., Aragonés J., Balsa E., Elorza A., Fernández-Criado C., Fuertes E., Manuel Ortiz de Landázuri, Miró-Murillo M., Ordóñez A., Soro-Arnáiz I., Vara-Vega A., Vazquez S.N.Fuentes:scopusMutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma
ArticleAbstract: Inactivation of the von Hippel-Lindau (VHL) tumor suppressor drives the development of clear-cell rePalabras claves:Autores:Acosta-Iborra B., Aragonés J., Balsa E., Elorza A., Fuertes-Yebra E., Manuel Ortiz de Landázuri, Ordóñez-NavadijoFuentes:scopusMyeloid hypoxia-lnducible factors in inflammatory diseases
ArticleAbstract: Hypoxia inducible factors (HIFI and HIF2) have emerged as central regulators of the activity of myelPalabras claves:Hypoxia, Hypoxia-inducible factor (HIF), inflammation, MacrophagesAutores:Acosta-Lborra B., Aragonés J., Elorza A., Manuel Ortiz de LandázuriFuentes:scopusLack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
ArticleAbstract: Hypoxia-inducible factors (HIF) belong to an evolutionary conserved family of transcription factors,Palabras claves:Autores:Alfranca A., Álvarez-Tejado M., Aragonés J., Manuel Ortiz de Landázuri, Peso L.D., Vara A.Fuentes:scopusInduction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting complex i activity
ArticleAbstract: The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation toPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Balsa E., Cadenas S., Corral-Escariz M., Elorza A., Enríquez J.A., Fuertes-Yebra E., López-Bernardo E., Manuel Ortiz de Landázuri, Martínez-Ruiz A., Ordóñez A., Perales-Clemente E., Soro I., Tello D.Fuentes:scopusMacrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-γ production through the HIF-1α transcription factor
ArticleAbstract: Low oxygen tension areas are found in inflamed or diseased tissues where hypoxic cells induce survivPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Calzada M.J., Elorza A., Manuel Ortiz de Landázuri, Martín-Cofreces N.B., Martin-Puig S., Miro M., Olazabal I.M., Sánchez‐Madrid F.Fuentes:scopusMitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease
ReviewAbstract: Under hypoxic conditions, mitochondria can represent a threat to the cell because of their capacityPalabras claves:Hypoxia-inducible factor, Ischaemia, Mitochondria, preconditioning, Prolyl hydroxylaseAutores:Aragonés J., Cadenas S., Manuel Ortiz de LandázuriFuentes:scopusReduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions
ArticleAbstract: The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subseqPalabras claves:adhesion, antioxidant, flow, Hypoxia, NeutrophilAutores:Aragonés J., Del Pozo M.A., Luscinskas F.W., Manuel Ortiz de Landázuri, Montoya M.C.Fuentes:scopusPyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: Modulation of NF- κB and AP-1 transcription factors activity
ArticleAbstract: Endothelial cells (EC) play a key role in the inflammatory response, both by the production of proinPalabras claves:Autores:Alfranca A., Aragonés J., Castellanos M.D.C., Manuel Ortiz de Landázuri, Muñoz C., Pascual-Salcedo D., Redondo J.M., Vara A.Fuentes:scopus