Mostrando 10 resultados de: 22
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Journal of Biological Chemistry(5)
Blood(2)
Biochemical and Biophysical Research Communications(1)
Cancer Discovery(1)
Cancer Research(1)
15-Deoxy-Δ<sup>12,14</sup>-prostaglandin-J<inf>2</inf> reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation
ArticleAbstract: Hypoxia-inducible factor-1α (HIF-1α) protein is degraded under normoxia by its association to von HiPalabras claves:15-Deoxy-Δ -prostaglandin- J 12,14 2, Calpain, Heat shock protein-90, Hypoxia inducible factor, Lysosome, Proximal tubular cellsAutores:Aragonés J., Arenas M.I., Bienes R., Calzada M.J., Garcia-Bermejo M.L., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G.Fuentes:scopusCD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
ArticleAbstract: CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognatePalabras claves:CD69, HIF-1α, Hypoxia, tumor microenvironment, tumor-infiltrating lymphocytes (TILs)Autores:Aragonés J., Aznar M.Á., Azpilikueta A., Bolaños E., de la Fuente H., Etxeberria I., Garasa S., Labiano S., Maiso P., Manuel Ortiz de Landázuri, Meléndez-Rodríguez F., Melero I., Molina C., Palazón A., Sánchez-Paulete A.R., Sánchez‐Madrid F., Teijeira A.Fuentes:scopusActivation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase
ArticleAbstract: Hypoxia-inducible factors (HIF) are heterodimeric (α/β) transcription factors that play a fundamentaPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Castellanos M.C., Feijóo-Cuaresma M., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Temes E.Fuentes:scopusAcute Vhl gene inactivation induces cardiac HIF-Dependent erythropoietin gene expression
ArticleAbstract: Von Hippel Lindau (Vhl) gene inactivation results in embryonic lethality. The consequences of its inPalabras claves:Autores:Albacete-Albacete L., Aragonés J., Balsa E., Elorza A., Fernández-Criado C., Fuertes E., Manuel Ortiz de Landázuri, Miró-Murillo M., Ordóñez A., Soro-Arnáiz I., Vara-Vega A., Vazquez S.N.Fuentes:scopusGeneration of a highly sensitive reporter plasmid for the detection of the transcripcional response to hypoxia
ArticleAbstract: Decreased oxygen supply to the tissues at both systemic and local level induces a genic program whicPalabras claves:HIF-1α, Hypoxia, transcription factorsAutores:Alfranca A., Aragonés J., Manuel Ortiz de Landázuri, Temes E., Vara A.Fuentes:scopusEvidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adapPalabras claves:Autores:Alfranca A., Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., San Juan M.A., Vara A., Vidal F.Fuentes:scopusDithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage
ArticleAbstract: It has recently been shown that the alteration of the cell-redox status affects the transcription faPalabras claves:Autores:Aragonés J., Corbí A.L., Del Arco P.G., López-Cabrera M., López-Rodríguez C., Manuel Ortiz de Landázuri, Redondo J.M.Fuentes:scopusMutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma
ArticleAbstract: Inactivation of the von Hippel-Lindau (VHL) tumor suppressor drives the development of clear-cell rePalabras claves:Autores:Acosta-Iborra B., Aragonés J., Balsa E., Elorza A., Fuertes-Yebra E., Manuel Ortiz de Landázuri, Ordóñez-NavadijoFuentes:scopusMyeloid hypoxia-lnducible factors in inflammatory diseases
ArticleAbstract: Hypoxia inducible factors (HIFI and HIF2) have emerged as central regulators of the activity of myelPalabras claves:Hypoxia, Hypoxia-inducible factor (HIF), inflammation, MacrophagesAutores:Acosta-Lborra B., Aragonés J., Elorza A., Manuel Ortiz de LandázuriFuentes:scopusLack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
ArticleAbstract: Hypoxia-inducible factors (HIF) belong to an evolutionary conserved family of transcription factors,Palabras claves:Autores:Alfranca A., Álvarez-Tejado M., Aragonés J., Manuel Ortiz de Landázuri, Peso L.D., Vara A.Fuentes:scopus