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Chemico-Biological Interactions(2)
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Brain Research Bulletin(1)
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Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death
ArticleAbstract: Clusianone is a member of the polycyclic polyprenylated acylphloroglucinol family of natural productPalabras claves:Clusianone, HepG2 cell death, Mitochondria, nemorosone, Protonophore, UncouplerAutores:Alberici L.C., Curti C., Marín-Prida J., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Reis F.H.Z., Uyemura S.A.Fuentes:googlescopusC-Phycocyanin protects SH-SY5Y cells from oxidative injury, rat retina from transient ischemia and rat brain mitochondria from Ca<sup>2+</sup>/phosphate-induced impairment
ArticleAbstract: Oxidative stress and mitochondrial impairment are essential in the ischemic stroke cascade and eventPalabras claves:antioxidant, C-Phycocyanin, neuroprotection, Rat brain mitochondria, SH-SY5Y, Transient rat retinal ischemiaAutores:Alberici L.C., Alexey Llópiz-Arzuaga, Curti C., Leopoldino A.M., Liberato J.L., Marín-Prida J., Naal Z., Pardo-Andreu G.L., Pentón-Arias E., Pentón-Rol G., Polizello A.C.M., Rodrigues F.P., Rosa M.N., Santos W.F.d., Stringhetta K., Uyemura S.A.Fuentes:googlescopusA review of nemorosone: Chemistry and biological properties
ArticleAbstract: Nemorosone is a bicyclic polyprenylated acylphloroglucinol derivative originally isolated from ClusiPalabras claves:Acylphloroglucinols, Anti-Cancer, Clusiaceae, nemorosone, Pharmacological activityAutores:Fernández-Acosta R., Monzote L., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Rastrelli L.Fuentes:googlescopusA strong protective action of Guttiferone-A, a naturally occurring prenylated benzophenone, against iron-induced neuronal cell damage
ArticleAbstract: Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmPalabras claves:antioxidant, Guttiferone-A, Iron, Iron chelation, neuroprotectionAutores:Curti C., García-Pupo L., Naal Z., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., René D.H.Fuentes:googlescopusDiscerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities
ArticleAbstract: Oxidative stress resulting from iron and reactive oxygen species (ROS) homeostasis breakdown has beePalabras claves:antioxidant, Iron, Iron-chelation, Mitochondria, Quinones, RapanoneAutores:Antuch M., de la Vega-Hernández K., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L.Fuentes:googlescopusNeuroprotective action and free radical scavenging activity of guttiferone-A, a naturally occurring prenylated benzophenone
ArticleAbstract: Reactive oxygen species (ROS) are important mediators in a number of neurodegenerative diseases andPalabras claves:glutamate, Guttiferone-A, Hydrogen Peroxide, neuroprotective drug, PC12 cells, rat cortical neuronsAutores:Alcántara-Isaac Y., Curti C., García-Pupo L., Hernández R.D., Naal Z., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Ramírez-Sánchez J.Fuentes:googlescopusNovel Insights into the Molecular Mechanisms Involved in the Neuroprotective Effects of C-Phycocyanin against Brain Ischemia in Rats
ArticleAbstract: Background: Ischemic stroke produces a large health impact worldwide, with scarce therapeutic optionPalabras claves:Brain ischemia, C-Phycocyanin, Ischemic stroke, NADPH oxidase, neuroinflammation, neuroprotectionAutores:Alexey Llópiz-Arzuaga, Antoni Camins, Cruz O.G., González I.H., Leopoldino A.M., Liberato J.L., Marín-Prida J., Pardo-Andreu G.L., Pavón-Fuentes N., Pentón-Rol G., Pérez M.L., Santos W.F.D., Stringhetta-Padovani K., Uyemura S.A.Fuentes:googlescopusThe anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: Ensuing energetic and oxidative stress implications
ArticleAbstract: Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with cytotoxic action in viPalabras claves:Anti-cancer action, Guttiferone-A, HepG2 cells, Mitochondria, Mitochondrial membrane permeabilization, Oxidative Stress, UncouplingAutores:Alberici L.C., Curti C., Leopoldino A.M., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Pestana C.R., Rodrigues F.P., Tudella V.G., Uyemura S.A.Fuentes:googlescopusThe anti-cancer agent nemorosone is a new potent protonophoric mitochondrial uncoupler
ArticleAbstract: Nemorosone, a natural-occurring polycyclic polyprenylated acylphloroglucinol, has received increasinPalabras claves:Cáncer, HepG2 cell death, Mitochondria, nemorosone, Protonophore, UncouplerAutores:Alberici L.C., Curti C., Leopoldino A.M., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Pestana C.R., Rodrigues F.P., Tudella V.G., Uyemura S.A.Fuentes:googlescopusThe cytotoxic effects of brown Cuban propolis depend on the nemorosone content and may be mediated by mitochondrial uncoupling
ArticleAbstract: Three main types of Cuban propolis directly related to their secondary metabolite composition have bPalabras claves:Cuban propolis, Cytotoxic, Mitochondria, nemorosone, Toxicity, UncouplingAutores:Alberici L.C., Curti C., Dalalio F.M., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Reis F.H.Z., Uyemura S.A.Fuentes:googlescopus