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Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
ArticleAbstract: Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic linPalabras claves:Autores:Allemeersch J., Carr E.J., Chabot-Roy G., Dahlstrom J.E., Delghingaro-Augusto V., Di Marino D., Dooley J., Franckaert D., Gevaert K., Goodnow C.C., Jetten A.M., Josselyn E. Garcia-Perez, Lagou V., Lambrechts D., Laybutt D.R., Lesage S., Linterman M.A., Liston A., Lyssenko V., Nolan C.J., Oskolkov N., Overbergh L., Pasciuto E., Petrovsky N., Schlenner S.M., Schönefeldt S., Socha L., Tian L., Vandenbussche J.Fuentes:scopusCytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency
ArticleAbstract: Background: Severe combined immunodeficiency can be caused by loss-of-function mutations in genes inPalabras claves:Artemis, cytotoxic T-lymphocyte-associated protein 4, immune dysregulation, Leaky severe combined immunodeficiency, regulatory T cellAutores:Baron F., Humblet-Baron S., Josselyn E. Garcia-Perez, Liston A., Pasciuto E., Schönefeldt S.Fuentes:scopus