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Allelic variant UCP3-55CT gene in obese individuals with and without anthropometric and metabolic alterations in Maracaibo municipality, Zulia state

Abstract:

Background: The accumulation of body fat has a genetic basis. Given the importance of UCP3 in the regulation of energy balance, the aim of this study was to investigate the association of the UCP3 gene variant-55C/T (rs1800849) with anthropometric and metabolic abnormalities in obese individuals of Maracaibo Municipality, Zulia State. Materials and Methods: The population included 95 obese and 46 normal weight patients. Diagnosis of Metabolic Syndrome (MS) was done using IDF/AHA/NHLBI-2009 criteria. Genotypic analysis of UCP3 gene was performed by PCR-RFLP. Results and Discussion: The average values of BMI and abdominal circumference of the obese group was 34.2 ± 5 kg/m2 and 102.8 ± 14.2 cm, respectively. 54.7% of obese individuals exhibited multiple risk factors or MS, with decreased levels of HDL-C (62%) the predominant factor, followed by hypertension (55.8%) and hyperglycemia (52.6%). The heterozygous genotype-55C / T was detected more frequently in obese group (22%) compared with the control group (15.2%). The difference was more pronounced among obese with MS group (Ob/MS) and control group (p = 0.028). No significant difference in the genotype frequency -55C/T between Ob/MS and Ob /NotMS. Conclusion: The most significant finding in this study is the association of the UCP3 gene variant-55C/T with obesity, however it was not possible demonstrate association with anthropometric and metabolic parameters individuals. La contribution of this polymorphism to the development of obesity and other metabolic variables remains controversial, therefore required to extend the study study and incorporate other variables to evaluate gene-gene and gene-environment.