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3'UTR +62G>A polymorphism of the RETN gene coding resistin and its association with metabolic syndrome components

Abstract:

Background and objective: The polymorphism of the resistin gene (RETN/RSTN) has been associated with metabolic alterations. In this study the association between the 3'UTR +62G>A polymorphism and metabolic syndrome components was evaluated. Subjects and methods: The population (n = 218) was distributed in 3 groups: the control group with no metabolic alterations (n = 77), nSMA group with isolated metabolic alterations (n = 94) and MS group with metabolic syndrome (n = 47). The 3'UTR +62G>A polymorphism was analyzed by PCR-RFLP. Results: Central obesity was the most frequent alteration in both nSMA (56.4%) and MS (91.5%) groups followed by low c-HDL levels in the nSMA group (42.6%) and arterial hypertension in the MS group (85%). The frequency of the +62G/A genotype was 20.2% in the population. The G/A genotype was more frequently found in the MS (38.3%) and nSMA (17%) groups than in the control group (13%). The allelic distribution between the control group (+62G = 0.94, +62A = 0.06) and MS group (+62G = 0.81, +62A = 0.19) was significantly different (P =.0001). Significant associations between the G/A genotype and high values of abdominal circumference (P =.047), basal glycemia (P =.02) and systolic arterial pressure (P =.003) were found. Conclusion: The findings suggest the association between the G/A genotype and high values of systolic arterial pressure, basal glycemia and abdominal circumference. This association was independent of the metabolic syndrome context. © 2012 Elsevier España, S.L. All rights reserved.