P-112 Evaluation of Vitamin D Supplementation in Moderate to Severe Crohn's Disease Patients Using Anti-TNF: Replacement or Immunomodulation?

Abstract:

Background: Background: Vitamin D (VD) deficiency is common in patients with Crohn's disease (CD). It is believed that this deficiency is related to the CD activity. However, the role of VD as a cause or consequence this condition is still unclear. There is no consensus in the literature regarding the best dosage for replacement, or even if there is evidence of immunomodulatory activity of VD in CD. Aims: To evaluate the results of the VD replacement at different doses and check possible immunomodulatory action of vitamin D in patients with CD Methods: Methods: We conducted a double-blind, randomized, prospective study. Forty-two patients were selected with history of moderate to severe CD in use of anti-TNF, of both sexes, between 18 to 60 years, with dosage of 25-hydroxyvitamin D< 75 nmol/L (30 ng/mL) who signed the informed consent. Were excluded patients with less than 18 or over 60 years of age …

Año de publicación:

2017

Keywords:

Fuente:

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