Chemical analysis and screening as anticancer agent of anthocyanin-rich extract from uva caimarona (Pourouma cecropiifolia Mart.) fruit

Abstract:

The anthocyanin-rich extract (ARE) of the fruit from Pourouma cecropiifolia, a tropical plant native to the Amazon region, showed moderate cytotoxicity toward different cancer cell lines when evaluated by MTT assays. This extract was fractionated using Sephadex LH-20 chromatography to obtain three fractions (F1−F3), the composition of which was analyzed by HPLC-PDA and LC-ESI/MS. F1 was composed primarily of the monomeric anthocyanins delphinidin-3-O-β-glucopyranoside, cyanidin-3-O-β-glucopyranoside, and cyanidin-3-O-(6′′-malonyl)glucopyranoside. F2 contained the isomeric flavonols quercetin 3-O-α-rhamnopyranosyl-(1→6)-β-galactopyranoside and quercetin 3-O-α-rhamnopyranosyl-(1→6)-β-glucopyranoside, the structures of which were confirmed by 1H and 13C NMR. F3 contained polymeric pigments, which were analyzed using tandem ESI/MS with an ion trap-TOF. The structures of two …

Año de publicación:

2010

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Fuente:

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