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An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
ReviewAbstract: Importance of the field: The increase in life expectancy in developed countries has given rise to sePalabras claves:Alzheimer's disease, apoptosis, Neuroprotective drugs, Parkinson's DiseaseAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Sureda F.X., Verdaguer E., Zárate C.B.Fuentes:scopusAntiapoptotic drugs: A therapautic strategy for the prevention of neurodegenerative diseases
ReviewAbstract: The purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegPalabras claves:Alzheimer's disease, apoptosis, Cyclin-dependent kinases, Glutamate receptors, Neuronal cell death, Neuroprotective drugs. apoptosis, Parkinson's DiseaseAutores:Antoni Camins, Auladell C., Canudas A.M., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Sureda F.X., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusA novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet
ArticleAbstract: Background: Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the globaPalabras claves:Alzheimer’s disease, BACE1, BDNF, cognitive decline, dendritic spines, high-fat diet, neuroinflammation, Rhein-huprine hybrid, Tau, TLR4Autores:Antoni Camins, Auladell C., Bulló M., Cano A., Espinosa-Jimenez T., Ettcheto M., Folch J., Muñoz-Torrero D., Olloquequi J., Parcerisas A., Pont C., Sanchez-Lopez E., Verdaguer E.Fuentes:scopusDexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice
ArticleAbstract: Background: Several studies stablished a relationship between metabolic disturbances and Alzheimer´sPalabras claves:Alzheimer´s disease, APPswe/PS1dE9, Cognitive deficits, Dexibuprofen, High fat diet, Metabolic alterations, neuroinflammation, synapsis, unfolded protein response, βA plaquesAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Carrasco M., Espinosa-Jimenez T., Ettcheto M., Folch J., Herrera K., Manzine P.R., Olloquequi J., Sanchez-Lopez E., Verdaguer E.Fuentes:scopusCarnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats
ArticleAbstract: The neuroprotective effect of carnosine, an endogenous antioxidant, was examined against methamphetaPalabras claves:Benzodiazepine receptor, peripheral-type, Carnosine, HSP27, Methamphetamine, [ H]GBR 12935 3, [ H]Paroxetine 3Autores:Antoni Camins, Camarasa J., Escubedo E., Pallás M., Pubill D., Sureda F.X., Verdaguer E.Fuentes:scopusAging biology: A new frontier for drug discovery
ReviewAbstract: Introduction: The prevalence of age-related pathologies, such as cardiovascular disease, neurodegenePalabras claves:Autores:Antoni Camins, Auladell C., Folch J., Junyent F., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusAging control with resveratrol
ReviewAbstract: The prevalence of age-related pathologies such as neurodegenerative disease and diabetes type II hasPalabras claves:Autores:Antoni Camins, Junyent F., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusFlavopiridol: An antitumor drug with potential application in the treatment of neurodegenerative diseases
ArticleAbstract: Several lines of evidence show that cyclin-dependent kinases (CDKs) contribute to neurodegenerativePalabras claves:Autores:Antoni Camins, Canudas A.M., Jiménez A., Jordá E.G., Pallás M., Verdaguer E.Fuentes:scopusNeuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis
ArticleAbstract: Flavopiridol was developed as a drug for cancer therapy due to its ability to inhibit cell cycle proPalabras claves:Caspase-3, Cerebellar granule neurons, Cyclin-dependent kinases, flavopiridol, neuroprotection, Par-4Autores:Antoni Camins, Bravo R., Bruna A., Caelles C., Camarasa J., Canudas A.M., Escubedo E., Jiménez A., Jordá E.G., Pallás M., Pubill D., Verdaguer E.Fuentes:scopusNovel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates
ArticleAbstract: A new family of dual binding site acetylcholinesterase (AChE) inhibitors has been designed, synthesiPalabras claves:Acetylcholinesterase, drug design, Inhibitors, β-amyloid peptides, β-secretaseAutores:Andrisano V., Antoni Camins, Arce M.P., Badia A., Bartolini M., Bidon-Chanal A., Camps P., Clos M.V., Galdeano C., Gómez T., Junyent F., Luque F.J., Mancini F., Muñoz-Torrero D., Pallás M., Ramírez L., Ratia M., Rodríguez-Franco M.I., Verdaguer E., Viayna E.Fuentes:scopus