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2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis
ArticleAbstract: 2-MeTHF and CPME were evaluated as greener alternatives for the most employed solvents in peptide syPalabras claves:2-methyltetrahydrofuran, Cyclopentyl methyl ether, Green solvents, Peptide synthesis, Solid-phase peptide synthesisAutores:Acosta G.A., Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Khattab S.N., Kruger H.G.Fuentes:scopusDiethylphosphoryl-oxymab (DEPO-B) as a solid coupling reagent for amide bond formation
ArticleAbstract: A new phosphonium based coupling reagent DEPO-B has been synthesized from 5-(hydroxyimino)-1,3-dimetPalabras claves:coupling reagent, Diethylphosphoryl-OxymaB, Hydrolytic stability, Phosphonium salts, SOLUBILITYAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A.Fuentes:scopusFormation of N <sup>α</sup>-terminal 2-dialkyl amino oxazoles from guanidinated derivatives under mild conditions
ArticleAbstract: Oxazole-containing peptides are an important class of molecules in medicinal chemistry programs. HerPalabras claves:Autores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Mhlongo J.T., Monaim S.A.H.A.Fuentes:scopusGreen Solid-Phase Peptide Synthesis (GSPPS) 3. Green Solvents for Fmoc Removal in Peptide Chemistry
ArticleAbstract: DMF (N,N-dimethylformamide) is the most widely used solvent for Fmoc-SPPS, which is the conventionalPalabras claves:Fmoc, Green solvents, Peptide aggregation, Protecting groups, Solid-phase peptide synthesis, valerolactoneAutores:Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Kruger H.G.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusExploring the orthogonal chemoselectivity of 2,4,6-trichloro-1,3,5-triazine (TCT) as a trifunctional linker with different nucleophiles: Rules of the game
ArticleAbstract: The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyPalabras claves:density functional theory, Electrostatic potential maps, NBO calculations, S-triazine, Triorthogonal linkerAutores:Alberício F., B. G. De la Torre, El-Faham A., Sharma A.Fuentes:scopusEnamine barbiturates and thiobarbiturates as a new class of bacterial urease inhibitors
ArticleAbstract: Urease is a therapeutic target associated with several important diseases and health problems. BasedPalabras claves:Barbituric, DFT, Pyrimidine-trione, Thiobarbituric, Urease inhibitorsAutores:Al-Majid A.M., Alberício F., Ali M., Ashraf S., B. G. De la Torre, Barakat A., Choudhary M.I., El-Faham A., Ul-Haq Z., Yousuf S.Fuentes:scopusEDC·HCl and Potassium Salts of Oxyma and Oxyma-B as Superior Coupling Cocktails for Peptide Synthesis
ArticleAbstract: Nowadays, DIC is the most widely used carbodiimide for solid-phase peptide synthesis, while EDC·HClPalabras claves:peptide coupling, Peptides, solid-phase synthesis, Steric hindrance, synthetic methodsAutores:Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Khattab S.N., Kruger H.G.Fuentes:scopusN-methylation in amino acids and peptides: Scope and limitations
ReviewAbstract: Active pharmaceutical ingbkp_redients (APIs) can be divided into two types, namely chemical and biolPalabras claves:cyclic peptides, NMAA, side-reactions, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A., Monaim S.A.H.A., Sharma A.Fuentes:scopusNovel pyrazolyl-s-triazine derivatives, molecular structure and antimicrobial activity
ArticleAbstract: A new series of pyrazole-containing s-triazine derivatives were synthesized by reaction of the correPalabras claves:Antibacterial activities, Cyanuric chloride, DFT/B3LYP, Hydrazino-s-triazine, Pyrazole, X-ray crystallographyAutores:Alberício F., B. G. De la Torre, El-Faham A., Ghabbour H.A., Khan S.T., Sharma A.Fuentes:scopus