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Bypassing osmotic shock dilemma in a polystyrene resin using the green solvent cyclopentyl methyl ether (CPME): A morphological perspective
ArticleAbstract: The "osmotic shock" phenomenon is the main thing that is responsible for morphological structure altPalabras claves:Green solvent, Osmotic shock, Solid-phase peptide synthesisAutores:Al Musaimi O., Alberício F., Almarhoon Z.M., B. G. De la Torre, Basso A., El-Faham A.Fuentes:scopus2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis
ArticleAbstract: 2-MeTHF and CPME were evaluated as greener alternatives for the most employed solvents in peptide syPalabras claves:2-methyltetrahydrofuran, Cyclopentyl methyl ether, Green solvents, Peptide synthesis, Solid-phase peptide synthesisAutores:Acosta G.A., Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Khattab S.N., Kruger H.G.Fuentes:scopusGreen Solid-Phase Peptide Synthesis (GSPPS) 3. Green Solvents for Fmoc Removal in Peptide Chemistry
ArticleAbstract: DMF (N,N-dimethylformamide) is the most widely used solvent for Fmoc-SPPS, which is the conventionalPalabras claves:Fmoc, Green solvents, Peptide aggregation, Protecting groups, Solid-phase peptide synthesis, valerolactoneAutores:Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Kruger H.G.Fuentes:scopusGreen Solid-Phase Peptide Synthesis 2. 2-Methyltetrahydrofuran and Ethyl Acetate for Solid-Phase Peptide Synthesis under Green Conditions
ArticleAbstract: N,N-Dimethylformamide (DMF), N-methyl-2-pyrrolidone, and dichloromethane (DCM) are the most widely uPalabras claves:2-MeTHF, Green Chemistry, Peptide aggregation, Polyethylene glycol resins, Solid-phase peptide synthesis, solid-phase synthesisAutores:Acosta G.A., Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Kruger H.G.Fuentes:scopusGreen solid-phase peptide synthesis 4. γ-Valerolactone and N-formylmorpholine as green solvents for solid phase peptide synthesis
ArticleAbstract: Herein, we report the use of γ-valerolactone (GVL) and N-formylmorpholine (NFM) as DMF substitutes iPalabras claves:Green solvents, GVL, NFM, polystyrene resin, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A.Fuentes:scopusGreening the Solid-Phase Peptide Synthesis Process. 2-MeTHF for the Incorporation of the First Amino Acid and Precipitation of Peptides after Global Deprotection
ArticleAbstract: In solid-phase peptide synthesis, dichloromethane is the predominant solvent used to incorporate thePalabras claves:2-MeTHF, Dipeptide formation, incorporation, precipitation, Racemization, Solid-phase peptide synthesisAutores:Al Musaimi O., Alberício F., B. G. De la Torre, Basso A., Collins J.M., El-Faham A., Jad Y.E., Kumar A.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusN-methylation in amino acids and peptides: Scope and limitations
ReviewAbstract: Active pharmaceutical ingbkp_redients (APIs) can be divided into two types, namely chemical and biolPalabras claves:cyclic peptides, NMAA, side-reactions, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A., Monaim S.A.H.A., Sharma A.Fuentes:scopusOxyma-T, expanding the arsenal of coupling reagents
ArticleAbstract: Herein, we report a new oxime-based additive (Oxyma-T) with a similar structure to HONM and Oxyma-BPalabras claves:Carbodiimides/additives, Oxime, Peptide coupling reagent, Solid-phase peptide synthesis, Solution-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Kruger H.G.Fuentes:scopusMinimizing side reactions during amide formation using DIC and oxymapure in solid-phase peptide synthesis
ArticleAbstract: N,N’-diisopropylcarbodiimide (DIC) and OxymaPure are the reagents of choice for the formation of pepPalabras claves:Carbodiimides, HCN formation, Oxadiazole, Side-reaction, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Manne S.R.Fuentes:scopus