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2,5-Diketopiperidine derivatives as non-peptide ligands for cholecystokinin receptors
ArticleAbstract: Easily accessible 2,5-diketopiperidines have been used as templates for the construction of Trp-PhePalabras claves:Autores:Del Río J., Dominguez M.J., Fortuno A., Garcı́a-López M.T., Gonzalez-Muniz R., Herranz R., Santiago J. BallazFuentes:googlescopus2-Oxopyrrolidines and 6-oxoperhydropyrrolo[1,2-a]pyrazines as templates in the search for nonpeptide cholecystokinin ligands
ArticleAbstract: In order to find new classes of non-peptide cholecystokinin (CCK) ligands, the conformational restriPalabras claves:2-Oxopyrrolidine, Cholecystokinin mimetic, Perhydropyrrolo[1,2-a]pyrazineAutores:Cenarruzabeitia E., Del Río J., Garcı́a-López M.T., Gonzalez-Muniz R., Herranz R., LaTorre M., Martín-Martínez M., Santiago J. BallazFuentes:googlescopus5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK<inf>1</inf> receptor antagonists: Structural modifications at the tryptophan domain
ArticleAbstract: Analogues of the previously reported potent and highly selective CCK1 receptor antagonist (4aS,5R)-2Palabras claves:Autores:Bartolomé-Nebreda J.M., Cenarruzabeitia E., Del Río J., Garcı́a-López M.T., Gómez-Monterrey I., Gonzalez-Muniz R., Herranz R., LaTorre M., Martín-Martínez M., Santiago J. BallazFuentes:scopusCCK-4 restricted analogues containing a 3-oxoindolizidine skeleton
ArticleAbstract: A series of CCK-4 restricted analogues, incorporating a 3-oxoindolizidine bicyclic lactam as conformPalabras claves:Autores:Barber A., Del Río J., Dominguez M.J., Garcı́a-López M.T., Gonzalez-Muniz R., Herranz R., Martín-Martínez M., Santiago J. BallazFuentes:googlescopusCCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum
ArticleAbstract: The possible interaction between cholecystokinin (CCK) and 5- hydroxytryptamine (5-HT) was evaluatedPalabras claves:Cholecystokinin, Contractile responses, Guinea-pig, Ileum, INTERACTION, SerotoninAutores:Barber A., Del Río J., Fortuno A., Santiago J. BallazFuentes:googlescopusFacilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors
ArticleAbstract: 1. Pretraining administration of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT 0.1 mg kg-1), a 5-Palabras claves:5-HT(1A) receptors, 8-OH-DPAT, EEDQ, hippocampus, Passive avoidanceAutores:Del Río J., Frechilla D., García-Osta A., Otano A., Santiago J. BallazFuentes:googlescopusMDMA ('Ecstasy') enhances 5-HT(1A) receptor density and 8-OH-DPAT- induced hypothermia: Blockade by drugs preventing 5-hydroxytryptamine depletion
ArticleAbstract: One week after a single administration of 3,4- methylenedioxymethamphetamine (MDMA · HCl, 30 mg/kg iPalabras claves:5-HT (serotonin, 5- hydroxytryptamine), 5-HT(1A) receptor, 8-OH-DPAT (8-hydroxy-2-(di-n- propylamino)tetralin), MDMA (3,4-methylenedioxymethamphetamine), TEMPERATUREAutores:Aguirre N., Del Río J., Lasheras B., Santiago J. BallazFuentes:googlescopusPharmacological evaluation of IQM-95,333, a highly selective CCK(A) receptor antagonist with anxiolytic-like activity in animal models
ArticleAbstract: 1. The pyridopyrimidine derivative IQM-95,333 ((4aS,5R)-2-benzyl-5-[N(α)-tert-butoxicarbonyl)L-tryptPalabras claves:Amylase release, Anxiolytic drugs, CCK(A) receptors, CCK(B) receptors, Cholecystokinin (CCK), Food intakeAutores:Barber A., Del Río J., Fortuno A., Garcı́a-López M.T., Gómez-Monterrey I., Gonzalez-Muniz R., Herranz R., Martín-Martínez M., Santiago J. BallazFuentes:scopusPseudopeptide CCK-4 analogues incorporating the Ψ[CH(CN)NH] peptide bond surrogate
ArticleAbstract: The synthesis, binding to CCK receptors, and in vitro functional activity of pseudopeptide CCK-4 anaPalabras claves:Autores:Barber A., Del Río J., Fortuno A., Garcı́a-López M.T., Gonzalez-Muniz R., Herranz R., Herrero S., Santiago J. Ballaz, Suárez-Gea M.L.Fuentes:scopusSynthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT<inf>1A</inf> receptors
ArticleAbstract: It has been proposed that 5-HT1A receptor antagonists augment the antidepressant efficacy of selectiPalabras claves:Autores:Del Castillo J., Del Río J., Donzella G., Guccione S., Hervías I., Krovat E., Langer T., Lasheras B., Martínez-Esparza J., Monge A., Mourelle M., Oficialdegui A., Orús L., Pérez-Silanes S., Poptodorov K., Santiago J. Ballaz, Tordera R.Fuentes:googlescopus