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Barbiturate- And Thiobarbituarte-Based s-Triazine Hydrazone Derivatives with Promising Antiproliferative Activities
ArticleAbstract: A new class of compounds, which include s-triazine with pyrimidinetrione or thiopyrimidinedione moiePalabras claves:Autores:Al-Rasheed H.H., Alberício F., B. G. De la Torre, Dahlous K.A., El-Faham A., Sharma A., Sholkamy E.N.Fuentes:scopusBreaking a Couple: Disulfide Reducing Agents
ReviewAbstract: Cysteine is present in a large number of natural and synthetic (bio)molecules. Although the thiol siPalabras claves:Cysteine, cystine, Disulfide bridges, reducing agents, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopus1,3,5-Triazine as core for the preparation of dendrons
ArticleAbstract: A unique property of 2,4,6-trichloro-1,3,5-triazine (TCT) is its ability to undergoes a nucleophilicPalabras claves:1+2 mode, Dendron, HPLC, Nucleophiles, S-triazineAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A., Sheyi R.Fuentes:scopus2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents
ArticleAbstract: Disulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synPalabras claves:Autores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusExploiting the Thiobarbituric Acid Scaffold for Antibacterial Activity
ArticleAbstract: Thiobarbituric acid (TBA) has been considered a privileged structure for developing antimicrobial agPalabras claves:Antibiotics, barbituric acid, nanoformulations, Thiobarbituric acidAutores:Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Hazzah H.A., Noki S., Sharma A., Zamisa S.J.Fuentes:scopusExploring the orthogonal chemoselectivity of 2,4,6-trichloro-1,3,5-triazine (TCT) as a trifunctional linker with different nucleophiles: Rules of the game
ArticleAbstract: The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyPalabras claves:density functional theory, Electrostatic potential maps, NBO calculations, S-triazine, Triorthogonal linkerAutores:Alberício F., B. G. De la Torre, El-Faham A., Sharma A.Fuentes:scopusFmoc-Amox, A Suitable Reagent for the Introduction of Fmoc
ArticleAbstract: Synthesis of most peptides is achieved using solid-phase peptide synthesis employing the Fmoc/tert-bPalabras claves:Autores:Alberício F., B. G. De la Torre, El-Faham A., Haimov E., Kumar A., Sharma A.Fuentes:scopusDisulfide-Based Protecting Groups for the Cysteine Side Chain
ArticleAbstract: Two new disulfide-based protecting groups (SIT and MOT) are proposed for Cys thiol in the substitutiPalabras claves:Autores:Alberício F., B. G. De la Torre, Chakraborty A., Sharma A.Fuentes:scopusEfficient route for synthesis of enamines from 1,3-alkyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Enols
ArticleAbstract: Here we report a greener approach for the synthesis of enamines from enols of 1,3-alkyl-2- thioxodihPalabras claves:Ammonium chloride, Enamines, Enols, Greener approach, HPLC, Thiobarbituric acidAutores:Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Sharma A.Fuentes:scopus