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Application of hexafluoroacetone as protecting and activating reagent in solid phase peptide and depsipeptide synthesis
ArticleAbstract: Hexafluoroacetone-protected/activated hydroxy acids [2,2- bis(trifluoromethyl)-1,3-dioxolan-4-ones]Palabras claves:Bidentate reagents, Citramalic acid, Hexafluoroacetone, Tetrahydroisoquinoline carboxylic acidAutores:Alberício F., Burger K., Cupido T., Jan Spengler, Ruiz J.Fuentes:googlescopusNO as temporary guanidino-protecting group provides efficient access to Pbf-protected argininic acid
ArticleAbstract: Pbf-protected argininic acid [H-OArg(Pbf)-OH], a building block for Fmoc-solid phase peptide synthesPalabras claves:arginine, Depsipeptides, side-reactions, Solid phase peptide synthesisAutores:Alberício F., Burger K., Cupido T., Jan SpenglerFuentes:googlescopusThe synthesis of naturally occurring peptides and their analogs
ReviewAbstract: The number of peptide-based pharmaceuticals has increased enormously over recent years; some of thesPalabras claves:Acyl migration, biosynthesis, Chemical ligation, cyclic peptides, NRP, Pharmaceutical peptide, Pseudoproline, resin, Solid phase, Total synthesis, Unnatural amino acidsAutores:Alberício F., Cupido T., Jan Spengler, Tulla-Puche J.Fuentes:googlescopus