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A modified variant of human Interleukin-15 as a novel antigen for active immunotherapy in rheumatoid arthritis
ReviewAbstract: Interleukin (IL)-15 is a pro-inflammatory cytokine that plays a crucial role in the pathogenesis ofPalabras claves:IL-15, Immunization, neutralizing antibodies, non-human primates, Rheumatoid ArthritisAutores:Alexey Llópiz-Arzuaga, Arrieta C.A., Besada-Pérez V., Castro-Velazco J., Eugenio Hardy, Geronimo H., Guillén-Nieto G.E., Martínez K., Martínez-Castillo R., Morera-Díaz Y., Moro A., Perea-Rodríguez S.E., Puente P., Ramos Y., Rodríguez-Álvarez Y., Santos-Savio A., Silva R., Vázquez M.Fuentes:scopusA synthetic conjugate polysaccharide vaccine against haemophilus influenzae type b
ArticleAbstract: Glycoconjugate vaccines provide effective prophylaxis against bacterial infections. To date, howeverPalabras claves:Autores:Aguilar A., Baly A., Campa C., Cardoso F., Carmenates A., Cosme K., Costa L., Deler M.L., Diaz M., Eugenio Hardy, Fernández-Santana V., Garcia E., Hernández I., Herrera L., Heynngnezz L., Izquierdo M., Medina E., Montane M., Muzachio A., Ramos A., Rodriguez A., Rodriguez M.C., Roy R., Sánchez R., Sosa I., Toledo-Romani M.E., Toraño G., Valdés Y., Verez-Bencomo V., Villar A.Fuentes:scopusComparative Serum Analyses Identify Cytokines and Hormones Commonly Dysregulated as Well as Implicated in Promoting Osteolysis in MMP-2-Deficient Mice and Children
ArticleAbstract: Deficiency of matrix metalloproteinase 2 (MMP-2) causes a complex syndrome characterized by multicenPalabras claves:cortisol, cytokines, Matrix metalloproteinase, matrix metalloproteinase-2, multicentric osteolysis nodulosis and arthropathyAutores:Botto L.D., Eugenio Hardy, Fernandez‐Patron C., Haimour A., Karim M.A., Martignetti J.A., Sarker H., Scholl-Bürgi S.Fuentes:scopusAntigenicity and immunogenicity of a synthetic oligosaccharide-protein conjugate vaccine against Haemophilus influenzae type b
ArticleAbstract: Polysaccharide-protein conjugates as vaccines have proven to be very effective in preventing HaemophPalabras claves:Autores:Cardoso F., Carmenate T., Chang J., Cosme K., Eugenio Hardy, Fernández-Santana V., Figueroa I., Hernández I., Heynngnezz L., Izquierdo M., Mawas F., Musacchio Lasa A., Peña L., Rodriguez A., Rodriguez M.C., Roy R., Toledo-Romani M.E., Valdés Y., Verez-Bencomo V.Fuentes:scopusCould Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?
ArticleAbstract: Endogenous glucocorticoids and their synthetic analogues, such as dexamethasone, stimulate receptor-Palabras claves:ACE2 (angiotensin converting enzyme 2), cortisol, covid-19, Dexamethasone, glucocorticoids, innate immunity, SARS-COV-2, Spike proteinAutores:Eugenio Hardy, Fernandez‐Patron C.Fuentes:scopusActive immunization with human interleukin-15 induces neutralizing antibodies in non-human primates
ArticleAbstract: Background: Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune andPalabras claves:Alum, CTLL-2 cells, Cytokine, IL-15, Immunization, Neutralizing Abs, non-human primatesAutores:Besada-Pérez V., Castro-Velazco J., Chico-Capote A., Eugenio Hardy, Gerónimo-Pérez H., Martínez-Castillo R., Martínez-Cordovez K., Morera-Díaz Y., Puente-Pérez P., Rodríguez-Álvarez Y., Santos-Savio A.Fuentes:scopusDevelopment of semisolid preparations for topical delivery of epidermal growth factor
Conference ObjectAbstract: Epidermal growth factor (EGF) is an endogenous protein of 53 amino acids residues isolated from submPalabras claves:Autores:Aguilera A., Berlanga-Acosta J., Eugenio Hardy, Garcia O., Herrera L., Lazcano R.R., Lorenzo R.R., Ramos L.Fuentes:scopusGlucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2
ArticleAbstract: Dexamethasone may reduce mortality in COVID-19 patients. Whether dexamethasone or endogenous glucocoPalabras claves:ACE2 (angiotensin converting enzyme 2), CORONAVIRUS, covid, glucocorticoids, innate immunity, SARS-COV-2Autores:Elahi S., Eugenio Hardy, Fernandez‐Patron C., Glover J.N.M., Panigrahi R., Sarker H.Fuentes:scopusEmerging pathways of communication between the heart and non-cardiac organs
ArticleAbstract: The breakthrough discovery of cardiac natriuretic peptides provided the first direct demonstration oPalabras claves:heart, inflammation, Liver, Matrix metalloproteinase, metabolism, microRNA, Natriuretic peptidesAutores:Eugenio Hardy, Fernandez‐Patron C.Fuentes:scopusIdentification of fibrinogen as a natural inhibitor of MMP-2
ArticleAbstract: Non-genetic MMP-2 insufficiency is a relatively unexplored condition which could be induced by pathoPalabras claves:Autores:Botto L.D., Eugenio Hardy, Fernandez‐Patron C., Haimour A., Maksymowych W.P., Sarker H.Fuentes:scopus